Fan Li1,2,3, Yuqin Wen1,2,3, Yan Zhang1,2,3, Kangyu Zheng1,2,3, Junfeng Ban1,2,3, Qingchun Xie1,2,3, Yifeng Wen1,2,3, Qing Liu1,2,3, Fohua Chen1,2,3, Zhenjie Mo1,2,3, Lizhong Liu4, Yanzhong Chen1,2,3, Zhufen Lu1,2,3. 1. Guangdong Provincial Key Laboratory of Advanced Drug Delivery Systems, Guangdong Pharmaceutical University, Guangzhou, People's Republic of China. 2. Guangdong Provincial Engineering Center of Topical Precise Drug Delivery Systems, Guangdong Pharmaceutical University, Guangzhou, People's Republic of China. 3. R&D Team for Formulation Innovation, Guangdong Pharmaceutical University, Guangzhou, People's Republic of China. 4. Department of Hospital Pharmacy, Ningbo 7 Hospital, Ningbo, People's Republic of China.
Abstract
Aim: 2-HP-β-cyclodextrin-PLGA nanoparticle complexes were prepared to enhance the aqueous humour delivery of Triamcinolone acetonide.Materials & methods: Drug-loaded 2-HP-β-CD/PLGA nanoparticle complexes prepared by adapting a quasi-emulsion solvent evaporation technique. In vitro drug release, in vitro transcorneal permeation study, histopathological study and in vivo transcorneal penetration of PLGA nanoparticles and 2-HP-β-CD/PLGA nanoparticle complexes were evaluated. Results: Particle size distributions of 2-HP-β-CD/PLGA nanoparticle complexes were 149.4 ± 3.7 nm and presented stable system. Corneal penetration studies revealed steady sustained drug release (First-order); 2-HP-β-CD/PLGA nanoparticle complexes increased ocular bioavailability by increasing dispersion in the tear film and improving drug release. Conclusion: 2-HP-β-CD/PLGA nanoparticle complex formulation is a promising alternative to conventional eye drops.
Aim: 2-HP-β-cyclodextrin-PLGA nanoparticle complexes were prepared to enhance the aqueous humour delivery of Triamcinolone acetonide.Materials & methods: Drug-loaded 2-HP-β-CD/PLGA nanoparticle complexes prepared by adapting a quasi-emulsion solvent evaporation technique. In vitro drug release, in vitro transcorneal permeation study, histopathological study and in vivo transcorneal penetration of PLGA nanoparticles and 2-HP-β-CD/PLGA nanoparticle complexes were evaluated. Results: Particle size distributions of 2-HP-β-CD/PLGA nanoparticle complexes were 149.4 ± 3.7 nm and presented stable system. Corneal penetration studies revealed steady sustained drug release (First-order); 2-HP-β-CD/PLGA nanoparticle complexes increased ocular bioavailability by increasing dispersion in the tear film and improving drug release. Conclusion: 2-HP-β-CD/PLGA nanoparticle complex formulation is a promising alternative to conventional eye drops.
Entities:
Keywords:
2-hydroxypropyl-beta-cyclodextrin; Hydrophilicity; PLGA nanoparticles; ocular drug delivery; triamcinolone acetonide
Authors: Astrid Pany; Marie Wohlgenannt; Safoura Klopprogge; Michael Wolzt; Thomas Heuser; Harald Kotisch; Claudia Valenta; Victoria Klang Journal: Int J Cosmet Sci Date: 2021-01-03 Impact factor: 2.970
Authors: Dawin Khiev; Zeinab A Mohamed; Riddhi Vichare; Ryan Paulson; Sofia Bhatia; Subhra Mohapatra; Glenn P Lobo; Mallika Valapala; Nagaraj Kerur; Christopher L Passaglia; Shyam S Mohapatra; Manas R Biswal Journal: Nanomaterials (Basel) Date: 2021-01-12 Impact factor: 5.076