Ligia Petrica1,2, Oana Milas1, Mihaela Vlad3, Adrian Vlad4, Florica Gadalean1, Victor Dumitrascu5, Silvia Velciov1, Cristina Gluhovschi1, Flaviu Bob1, Sorin Ursoniu2,6, Dragos C Jianu7, Petru Matusz8, Agneta-Maria Pusztai8, Octavian Cretu9, Daniela Radu10, Alina Secara1, Anca Simulescu1, Maria Stefan1, Roxana Popescu11, Daliborca Vlad5. 1. Department of Nephrology, 'Victor Babes' University of Medicine & Pharmacy, Romania. 2. Centre of Translational Research & Systems Medicine, 'Victor Babes' University of Medicine & Pharmacy, 300041 Timisoara, Romania. 3. Department of Endocrinology, 'Victor Babes' University of Medicine & Pharmacy, 300041 Timisoara, Romania. 4. Department of Diabetes & Metabolic Diseases, 'Victor Babes' University of Medicine & Pharmacy, 300041 Timisoara, Romania. 5. Department of Pharmacology, 'Victor Babes' University of Medicine & Pharmacy, 300041 Timisoara, Romania. 6. Department of Public Health Medicine, 'Victor Babes' University of Medicine & Pharmacy, 300041 Timisoara, Romania. 7. Department of Neurology, 'Victor Babes' University of Medicine & Pharmacy, 300041 Timisoara, Romania. 8. Department of Anatomy & Embryology, 'Victor Babes' University of Medicine & Pharmacy, 300041 Timisoara, Romania. 9. Department of Surgery I, 'Victor Babes' University of Medicine & Pharmacy, 300041 Timisoara, Romania. 10. Department of Surgery II, 'Victor Babes' University of Medicine & Pharmacy, 300041 Timisoara, Romania. 11. Department of Cellular & Molecular Biology, 'Victor Babes' University of Medicine & Pharmacy, 300041 Timisoara, Romania.
Abstract
Aim: The involvement of proinflammatory interleukins (IL) in diabetic kidney disease of Type 2 diabetes mellitus (DM) patients was studied in relation to a particular miRNA profile. Materials & methods: A total of 117 patients with Type 2 DM and 11 controls were enrolled in a case series study. Serum and urinary ILs and miRNAs were assessed. Results: IL-1α correlated with miRNA21, 124, estimated glomerular filtration rate (eGFR) and negatively with miRNA125a and 192; IL-8 with miRNA21, 124, eGFR and negatively with miRNA125a, 126 and 146a; IL-18 with miRNA21, 124 and negatively with miRNA146a, 192, eGFR. Conclusion: There is an association between specific serum and urinary ILs and serum and urinary miRNAs profiles in the inflammatory response in Type 2 DM patients with diabetic kidney disease.
Aim: The involvement of proinflammatory interleukins (IL) in diabetic kidney disease of Type 2 diabetes mellitus (DM) patients was studied in relation to a particular miRNA profile. Materials & methods: A total of 117 patients with Type 2 DM and 11 controls were enrolled in a case series study. Serum and urinary ILs and miRNAs were assessed. Results: IL-1α correlated with miRNA21, 124, estimated glomerular filtration rate (eGFR) and negatively with miRNA125a and 192; IL-8 with miRNA21, 124, eGFR and negatively with miRNA125a, 126 and 146a; IL-18 with miRNA21, 124 and negatively with miRNA146a, 192, eGFR. Conclusion: There is an association between specific serum and urinary ILs and serum and urinary miRNAs profiles in the inflammatory response in Type 2 DMpatients with diabetic kidney disease.