James C Dooley1,2, Greta Sokoloff1,2,3, Mark S Blumberg1,4,5,2,3. 1. Department of Psychological & Brain Sciences, University of Iowa, Iowa City, IA 52242, USA. 2. DeLTA Center, University of Iowa, Iowa City, IA 52242 USA. 3. Iowa Neuroscience Institute, University of Iowa, Iowa City, IA 52242 USA. 4. Interdisciplinary Graduate Program in Neuroscience, University of Iowa, Iowa City, IA 52245, USA. 5. Department of Biology, University of Iowa, Iowa City, IA, 52242 USA.
Abstract
PURPOSE OF REVIEW: Sleep-wake states modulate cortical activity in adults. In infants, however, such modulation is less clear; indeed, early cortical activity comprises bursts of neural activity driven predominantly by peripheral sensory input. Consequently, in many studies of sensory development in rodents, sensory processing has been carefully investigated, but the modulatory role of behavioral state has typically been ignored. RECENT FINDINGS: In the developing visual and somatosensory systems, it is now known that sleep and wake states modulate sensory processing. Further, in both systems, the nature of this modulation shifts rapidly during the second postnatal week, with subcortical nuclei changing how they gate sensory inputs. SUMMARY: The interactions among sleep and wake movements, sensory processing, and development are dynamic and complex. Now that established methods exist to record neural activity in unanesthetized infant animals, we can provide a more comprehensive understanding of how infant sleep-wake states interact with sensory-driven responses to promote developmental plasticity.
PURPOSE OF REVIEW: Sleep-wake states modulate cortical activity in adults. In infants, however, such modulation is less clear; indeed, early cortical activity comprises bursts of neural activity driven predominantly by peripheral sensory input. Consequently, in many studies of sensory development in rodents, sensory processing has been carefully investigated, but the modulatory role of behavioral state has typically been ignored. RECENT FINDINGS: In the developing visual and somatosensory systems, it is now known that sleep and wake states modulate sensory processing. Further, in both systems, the nature of this modulation shifts rapidly during the second postnatal week, with subcortical nuclei changing how they gate sensory inputs. SUMMARY: The interactions among sleep and wake movements, sensory processing, and development are dynamic and complex. Now that established methods exist to record neural activity in unanesthetized infant animals, we can provide a more comprehensive understanding of how infant sleep-wake states interact with sensory-driven responses to promote developmental plasticity.
Entities:
Keywords:
Cortical development; REM sleep; activity-dependent development; movement; somatosensory system; visual system
Authors: Anton Tokariev; Michael Breakspear; Mari Videman; Susanna Stjerna; Lianne H Scholtens; Martijn P van den Heuvel; Luca Cocchi; Sampsa Vanhatalo Journal: Cereb Cortex Date: 2022-05-31 Impact factor: 4.861