Anthoula Chatzikyriakidou1, Angeliki Chorti2, Theodosios Papavramidis2. 1. Laboratory of Medical Biology - Genetics, Faculty of Medicine, School of Health Sciences, Aristotle University, Thessaloniki, Greece chatzikyra@auth.gr. 2. First Propedeutic Department of Surgery, AHEPA University Hospital, Faculty of Medicine, School of Health Sciences, Aristotle University, Thessaloniki, Greece.
Abstract
BACKGROUND/AIM: The incidence of thyroid cancer has increased predominantly due to an increase in papillary thyroid cancer (PTC). Alteration of toll-like receptor function has been reported to play a crucial role in carcinogenesis. The aim of the present study was to investigate predisposition to PTC associated with genetic markers of toll-like receptor and interleukin-1 receptor pathways involving nuclear factor kappa-light-chain-enhancer of activated B-cells (NF-ĸB) stimulation. Specifically, the study focused on the following genes: interleukin-1 receptor-associated kinase 1 (IRAK1, rs3027898), NF-ĸB inhibitor alpha (NFKBIA, rs696), NF-ĸB subunit 1 (NFKB1, rs28362491), and microRNA-146a (miR-146a, rs2910164). PATIENTS AND METHODS: Forty-eight unrelated patients with papillary cancer restricted to the thyroid gland and 93 healthy volunteers were enrolled in the study. RESULTS: A strong statistically significant difference was observed between patients with PTC and controls for IRAK1 rs3027898 variant. When the statistical analysis was replicated taking into account patient's sex, the rs3027898 A allele was revealed to be the risky variant in males. CONCLUSION: Additional studies in larger groups of patients of various origins are needed to validate these preliminary findings. Copyright
BACKGROUND/AIM: The incidence of thyroid cancer has increased predominantly due to an increase in papillary thyroid cancer (PTC). Alteration of toll-like receptor function has been reported to play a crucial role in carcinogenesis. The aim of the present study was to investigate predisposition to PTC associated with genetic markers of toll-like receptor and interleukin-1 receptor pathways involving nuclear factor kappa-light-chain-enhancer of activated B-cells (NF-ĸB) stimulation. Specifically, the study focused on the following genes: interleukin-1 receptor-associated kinase 1 (IRAK1, rs3027898), NF-ĸB inhibitor alpha (NFKBIA, rs696), NF-ĸB subunit 1 (NFKB1, rs28362491), and microRNA-146a (miR-146a, rs2910164). PATIENTS AND METHODS: Forty-eight unrelated patients with papillary cancer restricted to the thyroid gland and 93 healthy volunteers were enrolled in the study. RESULTS: A strong statistically significant difference was observed between patients with PTC and controls for IRAK1rs3027898 variant. When the statistical analysis was replicated taking into account patient's sex, the rs3027898 A allele was revealed to be the risky variant in males. CONCLUSION: Additional studies in larger groups of patients of various origins are needed to validate these preliminary findings. Copyright
Authors: Anthoula Chatzikyriakidou; Paraskevi V Voulgari; Ioannis Georgiou; Alexandros A Drosos Journal: Joint Bone Spine Date: 2010-09-25 Impact factor: 4.929