Gabriela Dogaru1, Adriana Bulboaca2, Paul Mihai Boarescu2, Lorena Ciumarnean3, Vasile Rus4, Adela-Viviana Sitar-Taut5, Constantin Munteanu6, Gyorgy Bodisz7, Ioana Stanescu8. 1. Department of Medical Rehabilitation, "Iuliu Haţieganu" University of Medicine and Pharmacy, Cluj-Napoca, Romania. 2. Department of Pathophysiology, "Iuliu Haţieganu" University of Medicine and Pharmacy, Cluj-Napoca, Romania. 3. 5th Department of Internal Medicine, "Iuliu Haţieganu" University of Medicine and Pharmacy Cluj-Napoca, Cluj-Napoca, Romania. 4. Department of Cell Biology, Histology and Embryology, University of Agricultural Sciences and Veterinary Medicine, Cluj-Napoca, Romania vasile.rus@usamvcluj.ro. 5. Department of Internal Medicine, "Iuliu Haţieganu" University of Medicine and Pharmacy, Cluj-Napoca, Romania. 6. Department of Medical Rehabilitation, "Bagdasar Arseni" Emergency Clinical Hospital Bucharest, Bucharest, Romania. 7. Clinical Rehabilitation Hospital, Cluj-Napoca, Romania. 8. Department of Neurology, "Iuliu Haţieganu" University of Medicine and Pharmacy, Cluj-Napoca, Romania.
Abstract
BACKGROUND/AIM: Natural mofettes are gases resulting from post-volcanic emanations. This study aimed to examine the effect of mofette therapy on plasma oxidative stress and antioxidant parameters in rats after experimental induction of myocardial ischemia, as well as on structural changes in myocardial tissue. MATERIALS AND METHODS: White Wistar-Bratislava rats were divided into three groups. In groups 2 and 3, myocardial ischemia was induced by isoproterenol. Rats in group 3 were additionally exposed to high levels mofettes. Oxidative stress and antioxidant parameters were determined in plasma. The structural changes of the myocardium were observed in paraffin embedded slices contrasted using Goldner's trichrome staining. RESULTS: A statistically significant change in serum oxidative stress biomarkers, including nitric oxide, malondialdehyde, total oxidant status, as well as in the tested antioxidant molecules and total antioxidant capacity were observed in group 3 compared to group 2. Also, rats of group 3 showed an obvious improvement in inflammatory infiltration and repair of necrotic areas through collagen proliferation (proliferation of fibrous connective tissue) compared to group 2. CONCLUSION: Mofette had a beneficial effect on the balance between oxidative stress and antioxidant status following experimentally induced myocardial ischemia. Copyright
BACKGROUND/AIM: Natural mofettes are gases resulting from post-volcanic emanations. This study aimed to examine the effect of mofette therapy on plasma oxidative stress and antioxidant parameters in rats after experimental induction of myocardial ischemia, as well as on structural changes in myocardial tissue. MATERIALS AND METHODS: White Wistar-Bratislava rats were divided into three groups. In groups 2 and 3, myocardial ischemia was induced by isoproterenol. Rats in group 3 were additionally exposed to high levels mofettes. Oxidative stress and antioxidant parameters were determined in plasma. The structural changes of the myocardium were observed in paraffin embedded slices contrasted using Goldner's trichrome staining. RESULTS: A statistically significant change in serum oxidative stress biomarkers, including nitric oxide, malondialdehyde, total oxidant status, as well as in the tested antioxidant molecules and total antioxidant capacity were observed in group 3 compared to group 2. Also, rats of group 3 showed an obvious improvement in inflammatory infiltration and repair of necrotic areas through collagen proliferation (proliferation of fibrous connective tissue) compared to group 2. CONCLUSION: Mofette had a beneficial effect on the balance between oxidative stress and antioxidant status following experimentally induced myocardial ischemia. Copyright
Authors: Adriana Elena Bulboacă; Alina S Porfire; Lucia R Tefas; Paul Mihai Boarescu; Sorana D Bolboacă; Ioana C Stănescu; Angelo Corneliu Bulboacă; Gabriela Dogaru Journal: Molecules Date: 2019-02-27 Impact factor: 4.411
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Authors: Ioana Boarescu; Paul-Mihai Boarescu; Raluca Maria Pop; Ioana Corina Bocșan; Dan Gheban; Ruxandra-Mioara Râjnoveanu; Armand Râjnoveanu; Adriana Elena Bulboacă; Anca Dana Buzoianu; Sorana D Bolboacă Journal: Biomedicines Date: 2021-12-28