Kil Jun Jeong1, Euisin Yang1,2, Kwangsik Jang1,2, Kyung Mi Shim1,2, Chun-Sik Bae1, Se Eun Kim3,2, Seong Soo Kang3,2. 1. Department of Veterinary Surgery, College of Veterinary Medicine, Chonnam National University, Gwangju, Republic of Korea. 2. BK21 Plus Project Team and Biomaterial R&BD Center, Chonnam National University, Gwangju, Republic of Korea. 3. Department of Veterinary Surgery, College of Veterinary Medicine, Chonnam National University, Gwangju, Republic of Korea ksevet@gmail.com vetkang@chonnam.ac.kr.
Abstract
BACKGROUND/AIM: In Korea, small breed dogs including Maltese, Pomeranians, and Yorkshire Terriers are most common. These small dogs are at increased risk for the development of delayed union or nonunion fractures, particularly when the fracture occurs at a site with insufficient surrounded soft tissue such as the ulna and radius. To treat failed bone fracture healing, stable fixation of the fracture and implantation of bone grafts are needed. Among the various types of bone grafts, autograft is considered to be the gold standard. However, the amount of autograft available for harvesting in small dogs is limited. In this study, we report on a novel canine cancellous allograft (C350C) that was prepared using chemicals and low heat treatment (350°C). PATIENTS AND METHODS: We applied C350C in two cases with failed bone fracture healing. Due to the poor osteoinductive capabilities of C350C, we also used recombinant human bone morphogenetic protein-2 (rhBMP-2) and Matrigel as osteoinductive and delivery agents, respectively. RESULTS: In both cases, the fractures healed successfully. CONCLUSION: C350C can be used as a bone graft material that could replace autografts in cases with failed bone fracture healing. Copyright
BACKGROUND/AIM: In Korea, small breed dogs including Maltese, Pomeranians, and Yorkshire Terriers are most common. These small dogs are at increased risk for the development of delayed union or nonunion fractures, particularly when the fracture occurs at a site with insufficient surrounded soft tissue such as the ulna and radius. To treat failed bone fracture healing, stable fixation of the fracture and implantation of bone grafts are needed. Among the various types of bone grafts, autograft is considered to be the gold standard. However, the amount of autograft available for harvesting in small dogs is limited. In this study, we report on a novel canine cancellous allograft (C350C) that was prepared using chemicals and low heat treatment (350°C). PATIENTS AND METHODS: We applied C350C in two cases with failed bone fracture healing. Due to the poor osteoinductive capabilities of C350C, we also used recombinant humanbone morphogenetic protein-2 (rhBMP-2) and Matrigel as osteoinductive and delivery agents, respectively. RESULTS: In both cases, the fractures healed successfully. CONCLUSION: C350C can be used as a bone graft material that could replace autografts in cases with failed bone fracture healing. Copyright
Authors: Safdar N Khan; Frank P Cammisa; Harvinder S Sandhu; Ashish D Diwan; Federico P Girardi; Joseph M Lane Journal: J Am Acad Orthop Surg Date: 2005 Jan-Feb Impact factor: 3.020
Authors: L E Claes; C A Heigele; C Neidlinger-Wilke; D Kaspar; W Seidl; K J Margevicius; P Augat Journal: Clin Orthop Relat Res Date: 1998-10 Impact factor: 4.176