Nikolaos Machairas1, Anna Paspala2, Maximos Frountzas3, Diamantis I Tsilimigras4, Dimitrios Moris5, Vasileia Ntomi2, Dimitrios Tsapralis6, Dimitrios Schizas7. 1. 3rd Department of Surgery, National and Kapodistrian University of Athens, Attikon University Hospital, Athens, Greece nmachair@gmail.com. 2. 3rd Department of Surgery, National and Kapodistrian University of Athens, Attikon University Hospital, Athens, Greece. 3. Laboratory of Experimental Surgery and Surgical Research "N. S. Christeas", National and Kapodistrian University of Athens, Athens, Greece. 4. Department of Surgery, Division of Surgical Oncology, The Ohio State University Wexner Medical Center, Columbus, OH, U.S.A. 5. Department of Surgery, Duke University Medical Center, Durham, NC, U.S.A. 6. Department of Surgery, General Hospital of Ierapetra, Ierapetra, Greece. 7. 1st Department of Surgery, National and Kapodistrian University of Athens, Laikon Hospital, Athens, Greece.
Abstract
BACKGROUND/AIM: Mixed adenoneuroendocrine carcinomas (MANEC) are uncommon tumors exhibiting both adenocarcinomatous and neuroendocrine differentiation. They most commonly arise in the colon, appendix, rectum or stomach, however, a limited number of MANECs have been reported to originate in the gallbladder (gMANEC). The aim of our systematic review was to accumulate the existing data on gMANEC with special attention to the clinicopathological characteristics, surgical approach, recurrence and survival rates of patients diagnosed with this rare malignancy. MATERIALS AND METHODS: A comprehensive search of the literature was undertaken. RESULTS: A total of 15 studies (14 case reports and 1 case series), which comprised 19 patients who successfully underwent surgical treatment for gMANEC were included in our systematic review. During a median follow-up of 8 months (range=2-48 months) the overall survival was 87% and the recurrence rate was 21%. CONCLUSION: Achievement of complete surgical resection is the mainstay of the therapeutic management. Additionally, the stage of the disease and the histopathological mapping of these tumors affect decision-making for adjuvant chemotherapy and seem to define the prognostic course of each patient. Copyright
BACKGROUND/AIM: Mixed adenoneuroendocrine carcinomas (MANEC) are uncommon tumors exhibiting both adenocarcinomatous and neuroendocrine differentiation. They most commonly arise in the colon, appendix, rectum or stomach, however, a limited number of MANECs have been reported to originate in the gallbladder (gMANEC). The aim of our systematic review was to accumulate the existing data on gMANEC with special attention to the clinicopathological characteristics, surgical approach, recurrence and survival rates of patients diagnosed with this rare malignancy. MATERIALS AND METHODS: A comprehensive search of the literature was undertaken. RESULTS: A total of 15 studies (14 case reports and 1 case series), which comprised 19 patients who successfully underwent surgical treatment for gMANEC were included in our systematic review. During a median follow-up of 8 months (range=2-48 months) the overall survival was 87% and the recurrence rate was 21%. CONCLUSION: Achievement of complete surgical resection is the mainstay of the therapeutic management. Additionally, the stage of the disease and the histopathological mapping of these tumors affect decision-making for adjuvant chemotherapy and seem to define the prognostic course of each patient. Copyright
Authors: Adriano Carneiro da Costa; Fernando Santa-Cruz; Brena F Sena; Ademar Lopes; Nicole Leite; Alexandre Rolim da Paz; Álvaro A B Ferraz; José-Luiz Figueiredo Journal: World J Surg Oncol Date: 2018-11-12 Impact factor: 2.754
Authors: Shayna Brathwaite; Martha M Yearsley; Tanios Bekaii-Saab; Lai Wei; Carl R Schmidt; Mary E Dillhoff; Wendy L Frankel; John L Hays; Christina Wu; Sherif Abdel-Misih Journal: Front Oncol Date: 2016-06-13 Impact factor: 6.244
Authors: Adriano C Costa; Camilla L C Cavalcanti; Henrique G B Coelho; Luís Henrique A Leão; Daniel Tenório Camelo Soares; Fernando Santa-Cruz; Alexandre R Paz; Álvaro A B Ferraz Journal: Am J Case Rep Date: 2021-05-04