Literature DB >> 31662495

Understanding the Role of ztor in Aging-related Diseases Using the Zebrafish Model.

Eng-Soon Khor1, Suzita Mohd Noor2, Pooi-Fong Wong3.   

Abstract

The mammalian target of rapamycin (mTOR), a 289 kDa serine/threonine protein kinase of the phosphoinositide 3-kinase (PI3K)-related family is known for its role in regulating lifespan and the aging process in humans and rodents. Aging in zebrafish very much resembles aging in humans. Aged zebrafish often manifest with spinal curvature, cataracts and cognitive frailty, akin to human age-related phenotypical effects such as osteoarthritis, dwindling vision and cognitive dysfunction. However, the role of the zebrafish orthologue of mTOR, ztor, is less defined in these areas. This review paper discusses the tale of growing old in the zebrafish, the physiological roles of ztor in normal developmental processes and its involvement in the pathogenesis of aging-related diseases such as metabolic disorders and cancers. Copyright
© 2019, International Institute of Anticancer Research (Dr. George J. Delinasios), All rights reserved.

Entities:  

Keywords:  Aging-related diseases; developmental; mTOR; review; zebrafish; ztor

Mesh：

Substances：

Year:  2019        PMID： 31662495      PMCID： PMC6899122          DOI： 10.21873/invivo.11661

Source DB:  PubMed          Journal:  In Vivo        ISSN： 0258-851X            Impact factor:   2.155


  75 in total

Review 1.  Snail, Zeb and bHLH factors in tumour progression: an alliance against the epithelial phenotype?

Authors:  Héctor Peinado; David Olmeda; Amparo Cano
Journal:  Nat Rev Cancer       Date:  2007-05-17       Impact factor: 60.716

Review 2.  The mTOR pathway in the control of protein synthesis.

Authors:  Xuemin Wang; Christopher G Proud
Journal:  Physiology (Bethesda)       Date:  2006-10

Review 3.  mTORC1 signaling: what we still don't know.

Authors:  Xuemin Wang; Christopher G Proud
Journal:  J Mol Cell Biol       Date:  2010-12-07       Impact factor: 6.216

4.  Hypoxia-inducible factor 1alpha is closely linked to an aggressive phenotype in breast cancer.

Authors:  Yutaka Yamamoto; Mutsuko Ibusuki; Yasuhiro Okumura; Teru Kawasoe; Kazuharu Kai; Kenichi Iyama; Hirotaka Iwase
Journal:  Breast Cancer Res Treat       Date:  2007-09-06       Impact factor: 4.872

5.  Effect of aging and physical activity on left ventricular compliance.

Authors:  Armin Arbab-Zadeh; Erika Dijk; Anand Prasad; Qi Fu; Pilar Torres; Rong Zhang; James D Thomas; Dean Palmer; Benjamin D Levine
Journal:  Circulation       Date:  2004-09-13       Impact factor: 29.690

6.  Overexpression of Akt1 enhances adipogenesis and leads to lipoma formation in zebrafish.

Authors:  Che-Yu Chu; Chi-Fang Chen; R Samuel Rajendran; Chia-Ning Shen; Te-Hao Chen; Chueh-Chuan Yen; Chih-Kuang Chuang; Dar-Shong Lin; Chung-Der Hsiao
Journal:  PLoS One       Date:  2012-05-18       Impact factor: 3.240

7.  The identification of zebrafish mutants showing alterations in senescence-associated biomarkers.

Authors:  Shuji Kishi; Peter E Bayliss; Junzo Uchiyama; Eriko Koshimizu; Jie Qi; Purushothama Nanjappa; Shintaro Imamura; Asiful Islam; Donna Neuberg; Adam Amsterdam; Thomas M Roberts
Journal:  PLoS Genet       Date:  2008-08-15       Impact factor: 5.917

8.  Rapamycin inhibits the secretory phenotype of senescent cells by a Nrf2-independent mechanism.

Authors:  Rong Wang; Zhen Yu; Bharath Sunchu; James Shoaf; Ivana Dang; Stephanie Zhao; Kelsey Caples; Lynda Bradley; Laura M Beaver; Emily Ho; Christiane V Löhr; Viviana I Perez
Journal:  Aging Cell       Date:  2017-03-31       Impact factor: 9.304

Review 9.  The Continuum of Aging and Age-Related Diseases: Common Mechanisms but Different Rates.

Authors:  Claudio Franceschi; Paolo Garagnani; Cristina Morsiani; Maria Conte; Aurelia Santoro; Andrea Grignolio; Daniela Monti; Miriam Capri; Stefano Salvioli
Journal:  Front Med (Lausanne)       Date:  2018-03-12

10.  Active mechanistic target of rapamycin plays an ancillary rather than essential role in zebrafish CNS axon regeneration.

Authors:  Heike Diekmann; Pascal Kalbhen; Dietmar Fischer
Journal:  Front Cell Neurosci       Date:  2015-07-07       Impact factor: 5.505
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