Literature DB >> 31660951

Correction to: A novel tumor suppressor protein encoded by circular AKT3 RNA inhibits glioblastoma tumorigenicity by competing with active phosphoinositide-dependent Kinase-1.

Xin Xia1,2, Xixi Li1,2, Fanying Li1,2, Xujia Wu1,2, Maolei Zhang1,2, Huangkai Zhou1,2, Nunu Huang1,2, Xuesong Yang1,2, Feizhe Xiao3, Dawei Liu4, Lixuan Yang1,2, Nu Zhang5,6.   

Abstract

In the published article [1], an error was noticed in Fig. 6B. The western blot results were reversed between the overexpression group and the knockdown group of circ-AKT3. The corrected and updated Fig. 6 is provided below. This error does not affect the findings or conclusions of the article.

Entities:  

Year:  2019        PMID: 31660951      PMCID: PMC6819491          DOI: 10.1186/s12943-019-1083-2

Source DB:  PubMed          Journal:  Mol Cancer        ISSN: 1476-4598            Impact factor:   27.401


Correction to: Mol Cancer (2019) 18:131 https://doi.org/10.1186/s12943-019-1056-5 In the published article [1], an error was noticed in Fig. 6b. The western blot results were reversed between the overexpression group and the knockdown group of circ-AKT3. The corrected and updated Fig. 6 is provided below. This error does not affect the findings or conclusions of the article.
Fig. 6

AKT3-174aa competitively interacts with p-PDK1 form ATK2/3. a PDK1 kinase activity was determined in U251 and U373 cells with circ-AKT3 overexpression and their control cells at the indicated time point. Error bars represent three independent experiments, **, p < 0.01. b Upper, AKT kinase activity was determined in U251 and U373 cells with circ-AKT3 overexpression and their control cells (48 h); or in SW1783 and Hs683 cells with circ-AKT3 knocking down and their control cells (48 h). Error bars represent three independent experiments, *, p < 0.05, **, p < 0.01. Lower, p-SGK level was determined in indicated cells. c U251 cells were transfected with increasingly dose of circ-AKT3. IP was performed by using AKT2, AKT3 and p-PDK1 antibodies and followed by immunoblot using indicated antibodies. d SW1783 cells were transfected with increasingly dose of circ-AKT3 shRNA. IP was performed by using AKT2, AKT3 and p-PDK1 antibodies and followed by immunoblot using indicated antibodies

AKT3-174aa competitively interacts with p-PDK1 form ATK2/3. a PDK1 kinase activity was determined in U251 and U373 cells with circ-AKT3 overexpression and their control cells at the indicated time point. Error bars represent three independent experiments, **, p < 0.01. b Upper, AKT kinase activity was determined in U251 and U373 cells with circ-AKT3 overexpression and their control cells (48 h); or in SW1783 and Hs683 cells with circ-AKT3 knocking down and their control cells (48 h). Error bars represent three independent experiments, *, p < 0.05, **, p < 0.01. Lower, p-SGK level was determined in indicated cells. c U251 cells were transfected with increasingly dose of circ-AKT3. IP was performed by using AKT2, AKT3 and p-PDK1 antibodies and followed by immunoblot using indicated antibodies. d SW1783 cells were transfected with increasingly dose of circ-AKT3 shRNA. IP was performed by using AKT2, AKT3 and p-PDK1 antibodies and followed by immunoblot using indicated antibodies
  1 in total

1.  A novel tumor suppressor protein encoded by circular AKT3 RNA inhibits glioblastoma tumorigenicity by competing with active phosphoinositide-dependent Kinase-1.

Authors:  Xin Xia; Xixi Li; Fanying Li; Xujia Wu; Maolei Zhang; Huangkai Zhou; Nunu Huang; Xuesong Yang; Feizhe Xiao; Dawei Liu; Lixuan Yang; Nu Zhang
Journal:  Mol Cancer       Date:  2019-08-30       Impact factor: 27.401

  1 in total
  4 in total

1.  CircGSK3B promotes RORA expression and suppresses gastric cancer progression through the prevention of EZH2 trans-inhibition.

Authors:  Xianxiong Ma; Hengyu Chen; Lei Li; Feng Yang; Chuanqing Wu; Kaixiong Tao
Journal:  J Exp Clin Cancer Res       Date:  2021-10-19

Review 2.  Chimeric Peptides/Proteins Encoded by circRNA: An Update on Mechanisms and Functions in Human Cancers.

Authors:  Faiz Ali Khan; Bernard Nsengimana; Nazeer Hussain Khan; Zhenhua Song; Ebenezeri Erasto Ngowi; Yunyun Wang; Weijuan Zhang; Shaoping Ji
Journal:  Front Oncol       Date:  2022-02-11       Impact factor: 6.244

3.  A novel protein encoded by circHNRNPU promotes multiple myeloma progression by regulating the bone marrow microenvironment and alternative splicing.

Authors:  Xiaozhu Tang; Zhendong Deng; Pinggang Ding; Wanting Qiang; Yue Lu; Shengyao Gao; Ye Hu; Ye Yang; Juan Du; Chunyan Gu
Journal:  J Exp Clin Cancer Res       Date:  2022-03-08

Review 4.  Translation role of circRNAs in cancers.

Authors:  Yaqin Lu; Zhe Li; Chen Lin; Jian Zhang; Zhisen Shen
Journal:  J Clin Lab Anal       Date:  2021-06-07       Impact factor: 2.352

  4 in total

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