Aline Abadie1, Catherine Massoubre2, Léonie Casagranda3,4,5, Alice Protière2, Gaëlle Buisson-Papet6, Béatrice Trombert-Paviot5,7, Claire Freycon6, Florantina Isfan8, Cécile Faure-Conter9, Claire Berger3,4,5. 1. Department of General Medicine, Hospices Civils de Lyon, Lyon, France. 2. Department of Psychiatry, Centre Hospitalier Universitaire de Saint-Etienne, Saint-Etienne, France. 3. Department of Pediatric Hematology and Oncology Unit, University Hospital of Saint-Etienne, Saint-Etienne, France. 4. Childhood Cancer Registry of the Rhône-Alpes Region, Saint-Etienne, France. 5. Host Research Team EA4607 SNA-EPIS (Autonomic Nervous System, Epidemiology, Physiology, Exercise, and Health), Jean Monnet University of Saint-Etienne, PRES (Education and Research Cluster) Lyon, Saint-Etienne, France. 6. Department of Pediatric Hematology and Oncology, University Hospital Centre Grenoble Alpes, Grenoble, France. 7. Department of Public Health and Medical Informatics, Universite Jean Monnet Saint-Etienne Faculte de Medecine Jacques Lisfranc, Saint-Etienne, France. 8. Department of Pediatrics, Centre Hospitalier Universitaire de Clermont-Ferrand, Clermont-Ferrand, France. 9. Department of Pediatric Neuro-Oncology, Institut d'Hematologie et d'Oncologie Pediatrique, Lyon, France.
Abstract
Purpose: This study evaluated the long-term psychological impact of childhood cancer and also sought to identify the risk factors in the development of psychological issues. Methods: Young adult (18-38 years) survivors of a childhood cancer (except leukemia), diagnosed younger than 15 years between 1987 and 1999 in the Rhône-Alpes region of France, were invited to a semistandardized psychological interview after a medical follow-up consultation during two successive long-term follow-up studies in Oncology (SALTO-1 and -2). Psychiatric issues from the DSM-IV were diagnosed and compared with the general French population (GFP) through interviews based on the Mini-International Neuropsychiatric Interview (MINI). Results: Of the 288 childhood cancer survivors (CCSs) who attended the consultations, 247 completed the MINI interview. Fifty-five percent indicated they had suffered from psychiatric issues after their cancer compared to 31.9% of the GFP (p < 0.0001). These issues were generally anxiety problems (40.5%), mood disorders (28.7%), and substance dependency (10.5%; p < 0.0001). The risk of suicide was, however, less for the CCS group (8.9% vs. 13.6%, p = 0.03). Unemployment was a significant risk factor for mood disorders (p = 0.009). Men were 4.1 times more likely than women to be addicted during their lifetime (p = 0.0004), while adults cured of bone tumors were 14.3 times more likely to be at risk of drug dependence than adults cured of central nervous system tumors (p = 0.01). Conclusion: CCSs are particularly vulnerable to psychiatric disorders throughout their life. Systematic and long-term psychological monitoring of these patients will enable their psychiatric issues to be detected sooner.
Purpose: This study evaluated the long-term psychological impact of childhood cancer and also sought to identify the risk factors in the development of psychological issues. Methods: Young adult (18-38 years) survivors of a childhood cancer (except leukemia), diagnosed younger than 15 years between 1987 and 1999 in the Rhône-Alpes region of France, were invited to a semistandardized psychological interview after a medical follow-up consultation during two successive long-term follow-up studies in Oncology (SALTO-1 and -2). Psychiatric issues from the DSM-IV were diagnosed and compared with the general French population (GFP) through interviews based on the Mini-International Neuropsychiatric Interview (MINI). Results: Of the 288 childhood cancer survivors (CCSs) who attended the consultations, 247 completed the MINI interview. Fifty-five percent indicated they had suffered from psychiatric issues after their cancer compared to 31.9% of the GFP (p < 0.0001). These issues were generally anxiety problems (40.5%), mood disorders (28.7%), and substance dependency (10.5%; p < 0.0001). The risk of suicide was, however, less for the CCS group (8.9% vs. 13.6%, p = 0.03). Unemployment was a significant risk factor for mood disorders (p = 0.009). Men were 4.1 times more likely than women to be addicted during their lifetime (p = 0.0004), while adults cured of bone tumors were 14.3 times more likely to be at risk of drug dependence than adults cured of central nervous system tumors (p = 0.01). Conclusion: CCSs are particularly vulnerable to psychiatric disorders throughout their life. Systematic and long-term psychological monitoring of these patients will enable their psychiatric issues to be detected sooner.
Authors: Charlotte Sleurs; Jammbe Musoro; Ali Rowsell; Michal Kicinski; Stefan Suciu; Sofia Chantziara; Corneel Coens; Madeline Pe; Pierre Missotten; Els Vandecruys; Anne Uyttebroeck; Marie-Françoise Dresse; Claire Pluchart; Alina Ferster; Claire Freycon; Jutte van der Werff Ten Bosch; Pierre-Simon Rohrlich; Yves Benoit; Anne-Sophie Darlington; Caroline Piette Journal: Cancers (Basel) Date: 2021-12-29 Impact factor: 6.639