Dear Editor,We read with interest the article by Nori et al. analyzing burnout among infectious diseases (ID) faculty at an academic medical center in New York [1]. The authors used the Maslach Burnout Inventory–Human Services Survey (MBI-HSS) and an internally developed “ID Burnout Inventory” to assess the prevalence and etiologies of ID faculty burnout. That study found 53% of their ID faculty met criteria for burnout, but the vast majority of faculty also found their work rewarding. Further, women were significantly more likely to report stressors associated with work–life balance, childcare issues, and other domestic responsibilities. Reported drivers of burnout included lack of adequate support staff and financial compensation.To evaluate if the reported burnout was isolated to New York, we conducted the MBI-HSS among clinical ID faculty at an academic medical center in San Diego. Among the 32 clinical faculty invited, 19 completed the survey (10 women, 7 men, 2 declined to state). Ten were assistant, 2 were associate, and 7 were full professors. Eight reported spending >50% of their time doing clinical work. Twelve (63%) met criteria for high-level burnout; 47% had high emotional exhaustion scores, 47% had high depersonalization scores, and 37% had low personal accomplishment scores. Subgroups with the highest rates of burnout included women (70%), assistant professors (70%), faculty who spend <50% of their time doing clinical work (82%), and faculty who primarily work in our HIV primary care clinic (75%).Although limited by a small sample size and low response rate, our study was surprisingly consistent with Nori et al., which is alarming for several reasons. Burnout among ID faculty at academic medical centers does not appear to be isolated. Early career faculty, women, and those pursuing physician–scientist or HIV primary care careers appear to have the highest burnout. As fewer and fewer trainees are pursuing careers in the latter 2 pathways [2], we are concerned regarding our ability to recruit and maintain an ID physician–scientist and HIV clinical workforce for the future. Further, the gender disparities identified by Nori et al. and recapitulated in our study likely contribute to the challenges female ID physicians face in terms of career advancement, achieving leadership positions, and pay gap inequities. Although strategies to help manage and process burnout, such as mindfulness, self-care, and other strategies to enhance resilience, can be helpful in the short term [3], structural and systemic changes must also be enacted to preserve ID excellence within academic medical centers, where the next generation of ID physicians are trained. Such changes must address not only burnout but also the moral injury ID physicians often experience as a result of the business-oriented and profit-driven health care system, the documentation burden of electronic medical records, and the constant message that they are not valued beyond generating relative value units [4].