Yixuan Han1, Yanying Liu2, Xuejun Liu3, Wenhao Yang1, Ping Yu1, Jian Wang1, Yuqin Hu1, Rong Shu1, Haicheng Song1, Jierui Wang1, Wei Yuan1, Bailu Liu1, Na Li1, Huijing Shi1, Wenfang Yang1, Lina Li1, Yudi Hao2, Liufu Cui4. 1. Department of Rheumatology and Immunology, Affiliated Kailuan General Hospital of North China University of Science and Technology, 57 Xinhua East Street, Tangshan, 063000, China. 2. Department of Rheumatology and Immunology, Peking University People's Hospital, Beijing, 100044, China. 3. Department of thoracic surgery, Tangshan Gongren Hospital, Tangshan, 063000, China. 4. Department of Rheumatology and Immunology, Affiliated Kailuan General Hospital of North China University of Science and Technology, 57 Xinhua East Street, Tangshan, 063000, China. zjzzx163@163.com.
Abstract
OBJECTIVE: To explore whether cumulative serum urate (cumSU) is correlated with diabetes type II mellitus incidence. METHODS: In this study, we recruited individuals participating in all Kailuan health examinations from 2006 to 2013 without stroke, cancer, gestation, myocardial infarction, and diabetes type II diagnosis in the first three examinations. CumSU was calculated by multiplying the average serum urate concentration and the time between the two examinations (umol/L × year). CumSU levels were categorized into five groups: Q1-Q5. The effect of cumSU on diabetes type II incidence was estimated by logistic regression. RESULTS: A total of 36,277 individuals (27,077 men and 9200 women) participated in the final analysis. The multivariate logistic regression model showed the odds ratios (95% confidence intervals) of diabetes type II from Q1 to Q5 were 1.00 (reference), 1.25 (1.00 to 1.56), 1.43 (1.15 to 1.79), 1.49 (1.18 to 1.87), and 1.80 (1.40 to 2.32), respectively. Multivariable odds ratios per 1-standard deviation increase in cumSU were 1.26 (1.17 to 1.37) in all populations, 1.20 (1.10 to 1.32) for men, and 1.52 (1.27 to 1.81) for women, respectively. CONCLUSIONS: CumSU is a significant risk factor for diabetes type II. Individuals with higher cumSU, especially women, are at a higher risk of diabetes type II independent of other known risk factors.Key Points• Cumulative exposure to serum urate is a significant risk factor for diabetes type II.• Individuals with higher cumSU, especially women, are at a higher risk of diabetes type II.
OBJECTIVE: To explore whether cumulative serum urate (cumSU) is correlated with diabetes type II mellitus incidence. METHODS: In this study, we recruited individuals participating in all Kailuan health examinations from 2006 to 2013 without stroke, cancer, gestation, myocardial infarction, and diabetes type II diagnosis in the first three examinations. CumSU was calculated by multiplying the average serum urate concentration and the time between the two examinations (umol/L × year). CumSU levels were categorized into five groups: Q1-Q5. The effect of cumSU on diabetes type II incidence was estimated by logistic regression. RESULTS: A total of 36,277 individuals (27,077 men and 9200 women) participated in the final analysis. The multivariate logistic regression model showed the odds ratios (95% confidence intervals) of diabetes type II from Q1 to Q5 were 1.00 (reference), 1.25 (1.00 to 1.56), 1.43 (1.15 to 1.79), 1.49 (1.18 to 1.87), and 1.80 (1.40 to 2.32), respectively. Multivariable odds ratios per 1-standard deviation increase in cumSU were 1.26 (1.17 to 1.37) in all populations, 1.20 (1.10 to 1.32) for men, and 1.52 (1.27 to 1.81) for women, respectively. CONCLUSIONS: CumSU is a significant risk factor for diabetes type II. Individuals with higher cumSU, especially women, are at a higher risk of diabetes type II independent of other known risk factors.Key Points• Cumulative exposure to serum urate is a significant risk factor for diabetes type II.• Individuals with higher cumSU, especially women, are at a higher risk of diabetes type II.
Entities:
Keywords:
Cumulative serum urate; Diabetes type II; Risk factors
Authors: Abbas Dehghan; Mandy van Hoek; Eric J G Sijbrands; Albert Hofman; Jacqueline C M Witteman Journal: Diabetes Care Date: 2007-10-31 Impact factor: 19.112
Authors: Stephen P Juraschek; Mara McAdams-Demarco; Edgar R Miller; Allan C Gelber; Janet W Maynard; James S Pankow; Hunter Young; Josef Coresh; Elizabeth Selvin Journal: Am J Epidemiol Date: 2014-01-12 Impact factor: 4.897