Spyridon Champeris Tsaniras1,2, George J Delinasios3, Michalis Petropoulos4, Andreas Panagopoulos4, Athanasios K Anagnostopoulos3,5, Maria Villiou1, Dimitrios Vlachakis6, Vasiliki Bravou7, Georgios T Stathopoulos8, Stavros Taraviras9. 1. Department of Physiology, Medical School, University of Patras, Patras, Greece. 2. Cold Spring Harbor Laboratory, Cold Spring Harbor, NY, U.S.A. 3. International Institute of Anticancer Research, Kapandriti, Greece. 4. Department of Biology, School of Medicine, University of Patras, Patras, Greece. 5. Proteomics Research Unit, Biomedical Research Foundation of the Academy of Athens, Athens, Greece. 6. Bioinformatics & Medical Informatics Laboratory, Biomedical Research Foundation of the Academy of Athens, Athens, Greece. 7. Department of Anatomy-Histology-Embryology, Faculty of Medicine, University of Patras, Patras, Greece. 8. Laboratory for Molecular Respiratory Carcinogenesis, Department of Physiology, Faculty of Medicine, University of Patras, Patras, Greece. 9. Department of Physiology, Medical School, University of Patras, Patras, Greece taraviras@med.upatras.gr.
Abstract
BACKGROUND/AIM: Several links between DNA replication, pluripotency and development have been recently identified. The involvement of miRNA in the regulation of cell cycle events and pluripotency factors has also gained attention. MATERIALS AND METHODS: In the present study, we used the g:Profiler platform to analyze transcription factor binding sites, miRNA networks and protein-protein interactions to identify novel links among the aforementioned processes. RESULTS AND CONCLUSION: A complex circuitry between retinoic acid signaling, SWI/SNF components, pluripotency factors including Oct4, Sox2 and Nanog and cell cycle regulators was identified. It is suggested that the DNA replication inhibitor geminin plays a central role in this circuitry. Copyright
BACKGROUND/AIM: Several links between DNA replication, pluripotency and development have been recently identified. The involvement of miRNA in the regulation of cell cycle events and pluripotency factors has also gained attention. MATERIALS AND METHODS: In the present study, we used the g:Profiler platform to analyze transcription factor binding sites, miRNA networks and protein-protein interactions to identify novel links among the aforementioned processes. RESULTS AND CONCLUSION: A complex circuitry between retinoic acid signaling, SWI/SNF components, pluripotency factors including Oct4, Sox2 and Nanog and cell cycle regulators was identified. It is suggested that the DNA replication inhibitor geminin plays a central role in this circuitry. Copyright
Authors: Ruani N Fernando; Boris Eleuteri; Shaimaa Abdelhady; Andre Nussenzweig; Michael Andäng; Patrik Ernfors Journal: Proc Natl Acad Sci U S A Date: 2011-03-21 Impact factor: 11.205
Authors: Alexandra L Patmanidi; Nikolaos I Kanellakis; Dimitris Karamitros; Christos Papadimitriou; Zoi Lygerou; Stavros Taraviras Journal: Data Brief Date: 2016-03-12