OBJECTIVES: The logopenic variant of primary progressive aphasia (lvPPA) has disparate pathological and anatomical features when compared to the semantic (svPPA) and non-fluent (nfvPPA) variants of PPA. As such, there is increasing need for measures that improve diagnostic accuracy particularly when etiology-specific treatments become available. In the current study, we used meta-analytic methods to establish the neuropsychological profile of lvPPA and compare it to recent findings in svPPA and nfvPPA. METHODS: We extracted neuropsychological data from 51 publications representing 663 lvPPA patients and 1379 controls. We calculated Hedges' g effect sizes for nine domains of neuropsychological functioning in lvPPA and assessed the influence of demographic, disease, and task characteristics on effect size magnitude. Results obtained in lvPPA were compared to findings in svPPA and nfvPPA. RESULTS: In lvPPA, the magnitude of deficits in attention, math, visuospatial memory, and executive functioning were as prominent as language deficits. Within the language domain, lvPPA patients demonstrated greater naming than repetition deficits. Compared to svPPA and nfvPPA, lvPPA patients demonstrated greater neuropsychological deficits overall and greater impairment on attention, math, and visual set-shifting tests. CONCLUSIONS: Tests of attention, delayed visuospatial memory, visual set-shifting, and math distinguish lvPPA from svPPA and nfvPPA likely reflecting the posterior temporoparietal atrophy observed early in the course of lvPPA. These findings support the inclusion of these measures in the clinical neuropsychological assessment of lvPPA and underscore the need for additional clinicopathological and longitudinal studies of arithmetic and visuospatial memory across the PPA variants.
OBJECTIVES: The logopenic variant of primary progressive aphasia (lvPPA) has disparate pathological and anatomical features when compared to the semantic (svPPA) and non-fluent (nfvPPA) variants of PPA. As such, there is increasing need for measures that improve diagnostic accuracy particularly when etiology-specific treatments become available. In the current study, we used meta-analytic methods to establish the neuropsychological profile of lvPPA and compare it to recent findings in svPPA and nfvPPA. METHODS: We extracted neuropsychological data from 51 publications representing 663 lvPPA patients and 1379 controls. We calculated Hedges' g effect sizes for nine domains of neuropsychological functioning in lvPPA and assessed the influence of demographic, disease, and task characteristics on effect size magnitude. Results obtained in lvPPA were compared to findings in svPPA and nfvPPA. RESULTS: In lvPPA, the magnitude of deficits in attention, math, visuospatial memory, and executive functioning were as prominent as language deficits. Within the language domain, lvPPA patients demonstrated greater naming than repetition deficits. Compared to svPPA and nfvPPA, lvPPA patients demonstrated greater neuropsychological deficits overall and greater impairment on attention, math, and visual set-shifting tests. CONCLUSIONS: Tests of attention, delayed visuospatial memory, visual set-shifting, and math distinguish lvPPA from svPPA and nfvPPA likely reflecting the posterior temporoparietal atrophy observed early in the course of lvPPA. These findings support the inclusion of these measures in the clinical neuropsychological assessment of lvPPA and underscore the need for additional clinicopathological and longitudinal studies of arithmetic and visuospatial memory across the PPA variants.
Authors: Antoine Slegers; Geneviève Chafouleas; Maxime Montembeault; Christophe Bedetti; Ariane E Welch; Gil D Rabinovici; Philippe Langlais; Maria L Gorno-Tempini; Simona M Brambati Journal: Cortex Date: 2021-10-07 Impact factor: 4.644
Authors: D Foxe; A Hu; S C Cheung; R M Ahmed; N J Cordato; E Devenney; Y T Hwang; G M Halliday; N Mueller; C E Leyton; J R Hodges; J R Burrell; M Irish; O Piguet Journal: Brain Commun Date: 2022-07-07
Authors: Siddharth Ramanan; Muireann Irish; Karalyn Patterson; James B Rowe; Maria Luisa Gorno-Tempini; Matthew A Lambon Ralph Journal: Brain Date: 2022-09-14 Impact factor: 15.255
Authors: Hulya Ulugut; Simone Stek; Lianne E E Wagemans; Roos J Jutten; Maria Antoinette Keulen; Femke H Bouwman; Niels D Prins; Afina W Lemstra; Welmoed Krudop; Charlotte E Teunissen; Bart N M van Berckel; Rik Ossenkoppele; Frederik Barkhof; Wiesje M van der Flier; Philip Scheltens; Yolande A L Pijnenburg Journal: J Neurol Date: 2021-07-03 Impact factor: 4.849