Literature DB >> 31658426

CD103+ T and Dendritic Cells Indicate a Favorable Prognosis in Oral Cancer.

Y Xiao1, H Li1, L Mao1, Q C Yang1, L Q Fu1, C C Wu1, B Liu1,2, Z J Sun1,2.   

Abstract

T cells and dendritic cells (DCs) that are positive for the tissue-resident marker CD103 play a vital role in antitumor immunity. In this study, multiplexed immunohistochemistry was applied to stain CD103 and the T-cell marker CD8 as well as the DC marker CD11c on formalin-fixed, paraffin-embedded oral squamous cell carcinoma (OSCC) tissues. Then, the density of CD103+CD8+ and CD103+CD11c+ tumor-infiltrating lymphocytes (TILs) in the intratumoral and stromal regions was calculated, and the correlation of CD103+CD8+ TIL and CD103+CD11c+ TIL density with OSCC patient prognosis was analyzed. The results revealed that CD103+CD8+ TILs and CD103+CD11c+ TILs were abundant in the stromal region and that increased stromal CD103+CD8+ TIL and intratumoral CD103+CD11c+ TIL density indicated a favorable prognosis. Moreover, we freshly isolated TILs from OSCC samples and performed flow cytometry to verify that CD103+CD8+ TILs display a tissue-resident memory T-cell (Trm) phenotype, and we discriminated CD103+CD11c+ TILs from tumor-associated macrophages.

Entities:  

Keywords:  immunity; immunotherapy; oncology; oral and maxillofacial surgery; oral carcinogenesis; tumor microenvironment

Year:  2019        PMID： 31658426     DOI： 10.1177/0022034519882618

Source DB:  PubMed          Journal:  J Dent Res        ISSN： 0022-0345            Impact factor:   6.116


  7 in total

Review 1.  Mechanism of tumour microenvironment in the progression and development of oral cancer.

Authors:  Mohd Mughees; Anindita Sengupta; Sapna Khowal; Saima Wajid
Journal:  Mol Biol Rep       Date:  2021-01-25       Impact factor: 2.316

Review 2.  Association of CD103+ T cell infiltration with overall survival in solid tumors of the digestive tract and its potential in anti-PD-1 treatment: A review and meta-analysis.

Authors:  Wei Wei; Yun Ding; Jiajia He; Jun Wu
Journal:  Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub       Date:  2022-03-28       Impact factor: 1.245

3.  Identification of a novel immune gene panel in tongue squamous cell carcinoma.

Authors:  Jiwei Sun; Fengyuan Guo; Qingming Tang; Guangjin Chen; Jinfeng Peng; Yufeng Shen; Junyuan Zhang; Jingqiong Hu; Cheng Yang
Journal:  Am J Transl Res       Date:  2022-05-15       Impact factor: 3.940

4.  Long Non-coding RNA LINC02195 as a Regulator of MHC I Molecules and Favorable Prognostic Marker for Head and Neck Squamous Cell Carcinoma.

Authors:  Hao Li; Hong-Gang Xiong; Yao Xiao; Qi-Chao Yang; Shao-Chen Yang; Hong-Chao Tang; Wen-Feng Zhang; Zhi-Jun Sun
Journal:  Front Oncol       Date:  2020-05-06       Impact factor: 6.244

5.  A comprehensive profile of TCF1+ progenitor and TCF1- terminally exhausted PD-1+CD8+ T cells in head and neck squamous cell carcinoma: implications for prognosis and immunotherapy.

Authors:  Dikan Wang; Juan Fang; Shuqiong Wen; Qunxing Li; Jinming Wang; Lisa Yang; Wenxiao Dai; Huanzi Lu; Junyi Guo; Zhongyan Shan; Wenqiang Xie; Xiangqi Liu; Liling Wen; Jie Shen; Anxun Wang; Qianming Chen; Zhi Wang
Journal:  Int J Oral Sci       Date:  2022-02-14       Impact factor: 6.344

Review 6.  Tumor Infiltrating Lymphocyte (TIL) Therapy for Solid Tumor Treatment: Progressions and Challenges.

Authors:  Yueshui Zhao; Jian Deng; Shuangfeng Rao; Sipeng Guo; Jing Shen; Fukuan Du; Xu Wu; Yu Chen; Mingxing Li; Meijuan Chen; Xiaobing Li; Wanping Li; Li Gu; Yuhong Sun; Zhuo Zhang; Qinglian Wen; Zhangang Xiao; Jing Li
Journal:  Cancers (Basel)       Date:  2022-08-27       Impact factor: 6.575

7.  An oxidative stress-related prognostic signature for indicating the immune status of oral squamous cell carcinoma and guiding clinical treatment.

Authors:  Wei Lu; Changwei Yin; Tianqi Zhang; Yihua Wu; Shengyun Huang
Journal:  Front Genet       Date:  2022-09-23       Impact factor: 4.772
  7 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.