Milad Ashrafizadeh 1 , Zahra Ahmadi 2 , Tahereh Farkhondeh 3 , Saeed Samarghandian 4 Show Affiliations »
Abstract
BACKGROUND: MicroRNAs are endogenous, short, non-coding RNAs with the length as low as 20 to 25 nucleotides. These RNAs are able to negatively affect the gene expression at the post-transcriptional level. It has been demonstrated that microRNAs play a significant role in cell proliferation, cell migration, cell death, cell differentiation, infection, immune response, and metabolism. Besides, the dysfunction of microRNAs has been observed in a variety of cancers. So, modulation of microRNAs is of interest in the treatment of disorders. OBJECTIVE: The aim of the current review is to investigate the modulatory effect of propofol on microRNAs in cancer therapy. METHODS: This review was performed at PubMed, SCOPUS and Web of Science data-bases using keywords "propofol', "microRNA", "cancer therapy", "propofol + microRNA" and "propofol + miR". RESULTS: It was found that propofol dually down-regulates/upregulates microRNAs to exert its antitumor activity. In terms of oncogenesis microRNAs, propofol exert an inhibitory effect, while propofol significantly enhances the expression of oncosuppressor microRNAs. CONCLUSION: It seems that propofol is a potential modulator of microRNAs and this capability can be used in the treatment of various cancers. Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.net.
BACKGROUND: MicroRNAs are endogenous, short, non-coding RNAs with the length as low as 20 to 25 nucleotides. These RNAs are able to negatively affect the gene expression at the post-transcriptional level. It has been demonstrated that microRNAs play a significant role in cell proliferation, cell migration, cell death, cell differentiation, infection , immune response, and metabolism. Besides, the dysfunction of microRNAs has been observed in a variety of cancers . So, modulation of microRNAs is of interest in the treatment of disorders. OBJECTIVE: The aim of the current review is to investigate the modulatory effect of propofol on microRNAs in cancer therapy. METHODS: This review was performed at PubMed, SCOPUS and Web of Science data-bases using keywords "propofol ', "microRNA", "cancer therapy", "propofol + microRNA" and "propofol + miR" . RESULTS: It was found that propofol dually down-regulates/upregulates microRNAs to exert its antitumor activity. In terms of oncogenesis microRNAs, propofol exert an inhibitory effect, while propofol significantly enhances the expression of oncosuppressor microRNAs. CONCLUSION: It seems that propofol is a potential modulator of microRNAs and this capability can be used in the treatment of various cancers . Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.net.
Entities: Chemical
Disease
Gene
Keywords:
Propofol; anti-tumor activity; cancer therapy; microRNA; pharmacological targeting; signaling pathway.
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Year: 2020
PMID： 31657687 DOI： 10.2174/1568009619666191023100046
Source DB: PubMed Journal: Curr Cancer Drug Targets ISSN： 1568-0096 Impact factor: 3.428