| Literature DB >> 31657081 |
Shiming Zhang1,2,3,4, Yihang Chen2,3,5, Hao Liu1,2,3,6,7, Zitong Wang1,2,3, Haonan Ling2,3,8, Changsheng Wang9, Jiahua Ni1,2,3, Betül Çelebi-Saltik1,2,3, Xiaochen Wang1,2,3, Xiang Meng10, Han-Jun Kim1,2,3, Avijit Baidya1,2,3, Samad Ahadian1,2,3, Nureddin Ashammakhi2,3,11, Mehmet R Dokmeci2,3,11, Jadranka Travas-Sejdic12,13, Ali Khademhosseini1,2,3,11,14.
Abstract
There is an increasing need to develop conducting hydrogels for bioelectronic applications. In particular, poly(3,4-ethylenedioxythiophene):poly(styrenesulfonate) (PEDOT:PSS) hydrogels have become a research hotspot due to their excellent biocompatibility and stability. However, injectable PEDOT:PSS hydrogels have been rarely reported. Such syringe-injectable hydrogels are highly desirable for minimally invasive biomedical therapeutics. Here, an approach is demonstrated to develop injectable PEDOT:PSS hydrogels by taking advantage of the room-temperature gelation property of PEDOT:PSS. These PEDOT:PSS hydrogels form spontaneously after syringe injection of the PEDOT:PSS suspension into the desired location, without the need of any additional treatments. A facile strategy is also presented for large-scale production of injectable PEDOT:PSS hydrogel fibers at room temperature. Finally, it is demonstrated that these room-temperature-formed PEDOT:PSS hydrogels (RT-PEDOT:PSS hydrogel) and hydrogel fibers can be used for the development of soft and self-healable hydrogel bioelectronic devices.Entities:
Keywords: PEDOT:PSS hydrogel; healable; injectable; minimally invasive
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Year: 2019 PMID： 31657081 PMCID： PMC6946856 DOI： 10.1002/adma.201904752
Source DB: PubMed Journal: Adv Mater ISSN： 0935-9648 Impact factor: 30.849