P K Fazeli1,2,3, A T Faje4,5, E Meenaghan4, S T Russell4, M Resulaj4, H Lee5,6, C J Rosen7, M L Bouxsein5,8, A Klibanski4,5. 1. Neuroendocrine Unit, Massachusetts General Hospital, Boston, MA, USA. pkfazeli@pitt.edu. 2. Harvard Medical School, Boston, MA, USA. pkfazeli@pitt.edu. 3. Division of Endocrinology and Metabolism, University of Pittsburgh School of Medicine, 200 Lothrop Street, BST W1061, Pittsburgh, PA, 15213, USA. pkfazeli@pitt.edu. 4. Neuroendocrine Unit, Massachusetts General Hospital, Boston, MA, USA. 5. Harvard Medical School, Boston, MA, USA. 6. Biostatistics Center, Massachusetts General Hospital, Boston, MA, USA. 7. Maine Medical Center Research Institute, Scarborough, ME, USA. 8. Center for Advanced Orthopaedic Studies, Beth Israel Deaconess Medical Center, Boston, MA, USA.
Abstract
IGF-1 and leptin are two nutritionally dependent hormones associated with low bone mass in women with anorexia nervosa. Using finite element analysis, we estimated bone strength in women with anorexia nervosa and found that IGF-1 but not leptin correlated significantly with estimated bone strength in both the radius and tibia. PURPOSE: Women with anorexia nervosa, a psychiatric disorder characterized by self-induced starvation and low body weight, have impaired bone formation, low bone mass, and an increased risk of fracture. IGF-1 and leptin are two nutritionally dependent hormones that have been associated with low bone mass in women with anorexia nervosa. We hypothesized that IGF-1 and leptin would also be positively associated with estimated bone strength in women with anorexia nervosa. METHODS: In this cross-sectional study of 38 women (19 with anorexia nervosa and 19 normal-weight controls), we measured serum IGF-1 and leptin and performed finite element analysis of high-resolution peripheral quantitative CT images to measure stiffness and failure load of the distal radius and tibia. RESULTS: IGF-1 was strongly correlated with estimated bone strength in the radius (R = 0.52, p = 0.02 for both stiffness and failure load) and tibia (R = 0.55, p = 0.01 for stiffness and R = 0.58, p = 0.01 for failure load) in the women with anorexia nervosa but not in normal-weight controls. In contrast, leptin was not associated with estimated bone strength in the group of women with anorexia nervosa or normal-weight controls. CONCLUSIONS: IGF-1 is strongly associated with estimated bone strength in the radius and tibia in women with anorexia nervosa. Further studies are needed to assess whether treatment with recombinant human IGF-1 will further improve bone strength and reduce fracture risk in this population.
IGF-1 and leptin are two nutritionally dependent hormones associated with low bone mass in women with anorexia nervosa. Using finite element analysis, we estimated bone strength in women with anorexia nervosa and found that IGF-1 but not leptin correlated significantly with estimated bone strength in both the radius and tibia. PURPOSE:Women with anorexia nervosa, a psychiatric disorder characterized by self-induced starvation and low body weight, have impaired bone formation, low bone mass, and an increased risk of fracture. IGF-1 and leptin are two nutritionally dependent hormones that have been associated with low bone mass in women with anorexia nervosa. We hypothesized that IGF-1 and leptin would also be positively associated with estimated bone strength in women with anorexia nervosa. METHODS: In this cross-sectional study of 38 women (19 with anorexia nervosa and 19 normal-weight controls), we measured serum IGF-1 and leptin and performed finite element analysis of high-resolution peripheral quantitative CT images to measure stiffness and failure load of the distal radius and tibia. RESULTS:IGF-1 was strongly correlated with estimated bone strength in the radius (R = 0.52, p = 0.02 for both stiffness and failure load) and tibia (R = 0.55, p = 0.01 for stiffness and R = 0.58, p = 0.01 for failure load) in the women with anorexia nervosa but not in normal-weight controls. In contrast, leptin was not associated with estimated bone strength in the group of women with anorexia nervosa or normal-weight controls. CONCLUSIONS:IGF-1 is strongly associated with estimated bone strength in the radius and tibia in women with anorexia nervosa. Further studies are needed to assess whether treatment with recombinant humanIGF-1 will further improve bone strength and reduce fracture risk in this population.
Entities:
Keywords:
Anorexia nervosa; Finite element analysis; IGF-1; Leptin
Authors: Jason M Nagata; Neville H Golden; Mary B Leonard; Lawrence Copelovitch; Michelle R Denburg Journal: J Bone Miner Res Date: 2017-01-19 Impact factor: 6.741
Authors: Stephanie Boutroy; Bert Van Rietbergen; Elisabeth Sornay-Rendu; Francoise Munoz; Mary L Bouxsein; Pierre D Delmas Journal: J Bone Miner Res Date: 2008-03 Impact factor: 6.741
Authors: I Legroux-Gérot; J Vignau; E Biver; P Pigny; F Collier; X Marchandise; B Duquesnoy; B Cortet Journal: Osteoporos Int Date: 2010-01-06 Impact factor: 4.507
Authors: K K Miller; S Grinspoon; S Gleysteen; K A Grieco; J Ciampa; J Breu; D B Herzog; A Klibanski Journal: J Clin Endocrinol Metab Date: 2004-09 Impact factor: 5.958
Authors: Corrine K Welt; Jean L Chan; John Bullen; Robyn Murphy; Patricia Smith; Alex M DePaoli; Aspasia Karalis; Christos S Mantzoros Journal: N Engl J Med Date: 2004-09-02 Impact factor: 91.245
Authors: J A Langlois; C J Rosen; M Visser; M T Hannan; T Harris; P W Wilson; D P Kiel Journal: J Clin Endocrinol Metab Date: 1998-12 Impact factor: 5.958