Literature DB >> 31656618

A case report of photodermatoses induced by the antifungal drug terbinafine.

Astrid Bacle1,2, Sorya Belaz2,3, Sophie Potin1,2, Jean-Pierre Gangneux2,3.   

Abstract

Terbinafine is an antifungaldrug(inhibitor of ergosterol synthesis) known to induce skin reactions. A 58-year-old female was treated with terbinafine for onychomycosis. On the fifth day of treatment a skin rash emerged on her sun-exposed areas. Biological testing did not find any allergic signs. Other skin reactions are well known with terbinafine, but we depict here, a case of photosensitisation induced by treatment, generally unknown for this antifungal. This side effect can be prevented by medication reconciliation and pharmaceutical advice from the clinical pharmacist. © European Association of Hospital Pharmacists 2019. No commercial re-use. See rights and permissions. Published by BMJ.

Entities:  

Keywords:  clinical pharmacist; drug-induced photosensitivity; medication reconciliation; pharmaceutical advice; terbinafine

Year:  2018        PMID: 31656618      PMCID: PMC6788264          DOI: 10.1136/ejhpharm-2018-001683

Source DB:  PubMed          Journal:  Eur J Hosp Pharm        ISSN: 2047-9956


  6 in total

Review 1.  Photodermatoses, including phototoxic and photoallergic reactions (internal and external).

Authors:  Zekayi Kutlubay; Ayşegül Sevim; Burhan Engin; Yalçın Tüzün
Journal:  Clin Dermatol       Date:  2014 Jan-Feb       Impact factor: 3.541

Review 2.  UVB-sensitive solar urticaria possibly associated with terbinafine.

Authors:  Sandy Kuo; Raja K Sivamani
Journal:  Dermatol Online J       Date:  2014-03-17

3.  Systemic photoallergy to terbinafine.

Authors:  R Spiewak
Journal:  Allergy       Date:  2010-01-28       Impact factor: 13.146

Review 4.  Drug-induced photosensitivity: Photoallergic and phototoxic reactions.

Authors:  Ana Filipe Monteiro; Margarida Rato; César Martins
Journal:  Clin Dermatol       Date:  2016-05-20       Impact factor: 3.541

5.  Evaluation of Drug-Induced Photosensitivity Using the Japanese Adverse Drug Event Report (JADER) Database.

Authors:  Satoshi Nakao; Haruna Hatahira; Sayaka Sasaoka; Shiori Hasegawa; Yumi Motooka; Natsumi Ueda; Junko Abe; Akiho Fukuda; Misa Naganuma; Hiroyuki Kanoh; Mariko Seishima; Motoyuki Ishiguro; Yasutomi Kinosada; Mitsuhiro Nakamura
Journal:  Biol Pharm Bull       Date:  2017       Impact factor: 2.233

6.  Multiple-dose pharmacokinetics and distribution in tissue of terbinafine and metabolites.

Authors:  J M Kovarik; E A Mueller; H Zehender; J Denouël; H Caplain; L Millerioux
Journal:  Antimicrob Agents Chemother       Date:  1995-12       Impact factor: 5.191

  6 in total

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