M Ustrell-Borràs1, B Traboulsi-Garet, C Gay-Escoda. 1. Faculty of Medicine and Health Sciences, Oral Surgery and Implantology University of Barcelona, Campus de Bellvitge C/FeixaLlarg, s/n, Pavelló Govern, 2da Planta 08907 L'Hospitalet de Llobregat, Barcelona, Spain basselt.121@gmail.com.
Abstract
BACKGROUND: Oral and pharynx cancer represent a serious global problem, reaching an incidence of half a million cases annually. The role of tobacco and alcohol have been studied and proven to be one of its risk factors. We also know that mouthwashes contain a variable percentage of alcohol, so there is a reasonable concern about their role in carcinogenesis. MATERIALS AND METHODS: To answer the PICOS (Population; Intervention; Comparison; Outcomes; Study) question: "Do patients (Population) who use alcohol-based mouthwashes (Intervention) compared to those who do not use them (Comparison) have higher acetaldehyde levels in saliva or higher risk of oral cancer development? (Outcomes)" Meta-analyses, systematic reviews, randomized and non-randomized clinical trials, case-control studies, and prospective and retrospective cohort studies were included (Study). Two independent authors conducted literature screening through MEDLINE, Scopus and the Cochrane Library, and they also conducted article and data extraction to undertake quality analyses. The main outcome measures were salivary acetaldehyde levels or the risk of oral cancer development. The most relevant data was extracted and the risk of bias from the studies included was also evaluated. RESULTS: 497 references were obtained in the initial search. After eliminating the duplicates and evaluating titles and abstracts, a total of 26 articles were chosen to analyze the full text. 18 of these articles were excluded and finally 8 studies were included in the qualitative analysis: two meta-analyses, a clinical trial, three case-control studies and two cohort studies. CONCLUSIONS: It cannot be guaranteed that the use of mouthwash represents an independent risk factor for the development of head and neck cancer. However, the risk does increase when it occurs in association with other carcinogenic risk factors.
BACKGROUND: Oral and pharynx cancer represent a serious global problem, reaching an incidence of half a million cases annually. The role of tobacco and alcohol have been studied and proven to be one of its risk factors. We also know that mouthwashes contain a variable percentage of alcohol, so there is a reasonable concern about their role in carcinogenesis. MATERIALS AND METHODS: To answer the PICOS (Population; Intervention; Comparison; Outcomes; Study) question: "Do patients (Population) who use alcohol-based mouthwashes (Intervention) compared to those who do not use them (Comparison) have higher acetaldehyde levels in saliva or higher risk of oral cancer development? (Outcomes)" Meta-analyses, systematic reviews, randomized and non-randomized clinical trials, case-control studies, and prospective and retrospective cohort studies were included (Study). Two independent authors conducted literature screening through MEDLINE, Scopus and the Cochrane Library, and they also conducted article and data extraction to undertake quality analyses. The main outcome measures were salivary acetaldehyde levels or the risk of oral cancer development. The most relevant data was extracted and the risk of bias from the studies included was also evaluated. RESULTS: 497 references were obtained in the initial search. After eliminating the duplicates and evaluating titles and abstracts, a total of 26 articles were chosen to analyze the full text. 18 of these articles were excluded and finally 8 studies were included in the qualitative analysis: two meta-analyses, a clinical trial, three case-control studies and two cohort studies. CONCLUSIONS: It cannot be guaranteed that the use of mouthwash represents an independent risk factor for the development of head and neck cancer. However, the risk does increase when it occurs in association with other carcinogenic risk factors.
Authors: Dominik Radzki; Marta Wilhelm-Węglarz; Katarzyna Pruska; Aida Kusiak; Iwona Ordyniec-Kwaśnica Journal: Int J Environ Res Public Health Date: 2022-03-25 Impact factor: 3.390
Authors: Siti Aisyah Abd Ghafar; Nur Syahirah Salehuddin; Nor Zaihana Abdul Rahman; Nadia Halib; Rohazila Mohamad Hanafiah Journal: Evid Based Complement Alternat Med Date: 2022-06-21 Impact factor: 2.650