Literature DB >> 31653772

A new role for vault RNA-TEP1 complexes in mRNA production in trypanosomes.

Valerie A Kickhoefer1,2.   

Abstract

Vault RNAs, found in vault ribonucleoprotein complexes, are known to be one of many types of small noncoding RNAs (ncRNAs), but their specific function is not known. A new study identifies a small ncRNA from Trypanosome brucei as a vault RNA (vtRNA) based on sequence analysis and its association with the canonical vault component TEP1. Down-regulation of T. brucei vtRNA impairs mRNA splicing in a permeabilized cell system, suggesting new roles for these enigmatic biomolecules.
© 2019 Kickhoefer.

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Year:  2019        PMID： 31653772      PMCID： PMC6816098          DOI： 10.1074/jbc.H119.011130

Source DB:  PubMed          Journal:  J Biol Chem        ISSN： 0021-9258            Impact factor:   5.157


  7 in total

1.  Vaults are up-regulated in multidrug-resistant cancer cell lines.

Authors:  V A Kickhoefer; K S Rajavel; G L Scheffer; W S Dalton; R J Scheper; L H Rome
Journal:  J Biol Chem       Date:  1998-04-10       Impact factor: 5.157

2.  The Small Non-coding Vault RNA1-1 Acts as a Riboregulator of Autophagy.

Authors:  Rastislav Horos; Magdalena Büscher; Rozemarijn Kleinendorst; Anne-Marie Alleaume; Abul K Tarafder; Thomas Schwarzl; Dmytro Dziuba; Christian Tischer; Elisabeth M Zielonka; Asli Adak; Alfredo Castello; Wolfgang Huber; Carsten Sachse; Matthias W Hentze
Journal:  Cell       Date:  2019-02-14       Impact factor: 41.582

3.  The vault RNA of Trypanosoma brucei plays a role in the production of trans-spliced mRNA.

Authors:  Nikolay G Kolev; K Shanmugha Rajan; Kazimierz T Tycowski; Justin Y Toh; Huafang Shi; Yuling Lei; Shulamit Michaeli; Christian Tschudi
Journal:  J Biol Chem       Date:  2019-08-22       Impact factor: 5.157

Review 4.  Vaults and the major vault protein: novel roles in signal pathway regulation and immunity.

Authors:  W Berger; E Steiner; M Grusch; L Elbling; M Micksche
Journal:  Cell Mol Life Sci       Date:  2009-01       Impact factor: 9.261

5.  The Telomerase/vault-associated protein TEP1 is required for vault RNA stability and its association with the vault particle.

Authors:  V A Kickhoefer; Y Liu; L B Kong; B E Snow; P L Stewart; L Harrington; L H Rome
Journal:  J Cell Biol       Date:  2001-01-08       Impact factor: 10.539

6.  Loss of 5-methylcytosine alters the biogenesis of vault-derived small RNAs to coordinate epidermal differentiation.

Authors:  Abdulrahim A Sajini; Nila Roy Choudhury; Rebecca E Wagner; Susanne Bornelöv; Tommaso Selmi; Christos Spanos; Sabine Dietmann; Juri Rappsilber; Gracjan Michlewski; Michaela Frye
Journal:  Nat Commun       Date:  2019-06-11       Impact factor: 14.919

7.  The TROVE module: a common element in Telomerase, Ro and Vault ribonucleoproteins.

Authors:  Alex Bateman; Valerie Kickhoefer
Journal:  BMC Bioinformatics       Date:  2003-10-16       Impact factor: 3.169
  7 in total
  2 in total

1.  Human vtRNA1-1 Levels Modulate Signaling Pathways and Regulate Apoptosis in Human Cancer Cells.

Authors:  Lisamaria Bracher; Iolanda Ferro; Carlos Pulido-Quetglas; Marc-David Ruepp; Rory Johnson; Norbert Polacek
Journal:  Biomolecules       Date:  2020-04-16

Review 2.  The Vault Nanoparticle: A Gigantic Ribonucleoprotein Assembly Involved in Diverse Physiological and Pathological Phenomena and an Ideal Nanovector for Drug Delivery and Therapy.

Authors:  Gianni Frascotti; Elisabetta Galbiati; Matteo Mazzucchelli; Maria Pozzi; Lucia Salvioni; Jacopo Vertemara; Paolo Tortora
Journal:  Cancers (Basel)       Date:  2021-02-09       Impact factor: 6.639
  2 in total

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