Julie Winstanley1,2, Edward White2,3, Robyn Saw4, Teresa Young5, Bryan Burmeister6, Dejan Nikolic7,8, Iria Busto-Cornide9, Nicolás Iglesias-Pena10, Frances Boyle1,4. 1. Patricia Ritchie Centre for Cancer Care and Research, University of Sydney, Sydney, Australia. 2. White Winstanley Ltd, Cheshire, UK. 3. School of Psychiatry, University of New South Wales Sydney, Sydney, Australia. 4. Melanoma Institute Australia, University of Sydney, Sydney, Australia. 5. East & North Hertfordshire NHS Trust incorporating Mount Vernon Cancer Centre, Northwood, UK. 6. University of Queensland, Brisbane, Australia. 7. Faculty of Medicine, University of Belgrade, Belgrade, Serbia. 8. University Hospital Medical Center Bezanijska kosa, Belgrade, Serbia. 9. University of Santiago de Compostela, Galicia, Spain. 10. Complejo Hospitalario Universitario de A Coruña, A Coruña, Spain.
Abstract
OBJECTIVE: Few patient-reported outcome measures (PROMs) have been developed that adequately measure the patient-experience following diagnosis and treatment of melanoma. Building on previous research, which developed the European Organisation for Research and Treatment of Cancer (EORTC) Quality of Life Module (QLQ-MEL38), the aim of this study was to further test the hypothesised domain structure and psychometric properties of the phase 3 module, in a new larger sample of melanoma patients. METHODS: Melanoma patients (n = 270) were recruited from four countries (Australia, England, Serbia, and Spain). Patients completed the EORTC core questionnaire (QLQ-C30), the QLQ-MEL38, and a sociodemographic survey. Using this new larger dataset, comparisons were made with the hypothesised domain structure of the EORTC phase 3 module using principal component analysis. Items which formed subscales in a revised domain structure were then tested for goodness of fit (GoF) to the Rasch model. RESULTS: The original hypothesised and final domain structures were similar but not identical. Twenty-four items (83%) loaded onto the same distinct subscales previously generated by phase 3, and item-by-item comparison of the two pattern matrices indicated an extremely close match. Ten items were removed from the QLQ-MEL38 phase 3 module, and rescoring of some items was required. Four subscales, together with five individual items, comprised the final instrument. CONCLUSION: The newly developed measure (named the Melanoma Concerns Questionnaire; MCQ-28) was found to tap into several important psychosocial domains of concern to melanoma patients, particularly those being managed in "usual" clinic settings.
OBJECTIVE: Few patient-reported outcome measures (PROMs) have been developed that adequately measure the patient-experience following diagnosis and treatment of melanoma. Building on previous research, which developed the European Organisation for Research and Treatment of Cancer (EORTC) Quality of Life Module (QLQ-MEL38), the aim of this study was to further test the hypothesised domain structure and psychometric properties of the phase 3 module, in a new larger sample of melanomapatients. METHODS:Melanomapatients (n = 270) were recruited from four countries (Australia, England, Serbia, and Spain). Patients completed the EORTC core questionnaire (QLQ-C30), the QLQ-MEL38, and a sociodemographic survey. Using this new larger dataset, comparisons were made with the hypothesised domain structure of the EORTC phase 3 module using principal component analysis. Items which formed subscales in a revised domain structure were then tested for goodness of fit (GoF) to the Rasch model. RESULTS: The original hypothesised and final domain structures were similar but not identical. Twenty-four items (83%) loaded onto the same distinct subscales previously generated by phase 3, and item-by-item comparison of the two pattern matrices indicated an extremely close match. Ten items were removed from the QLQ-MEL38 phase 3 module, and rescoring of some items was required. Four subscales, together with five individual items, comprised the final instrument. CONCLUSION: The newly developed measure (named the Melanoma Concerns Questionnaire; MCQ-28) was found to tap into several important psychosocial domains of concern to melanomapatients, particularly those being managed in "usual" clinic settings.
Authors: Zachary Blood; Anh Tran; Lauren Caleo; Robyn Saw; Mbathio Dieng; Mark Shackleton; H Peter Soyer; Chris Arnold; Graham J Mann; Rachael L Morton Journal: BMJ Open Date: 2021-02-11 Impact factor: 2.692
Authors: Alessandro Borghi; Maria Elena Flacco; Alberto Monti; Lucrezia Pacetti; Michela Tabanelli; Monica Corazza Journal: Support Care Cancer Date: 2022-01-15 Impact factor: 3.359