Thomas Bahmer1,2, Jannie Marie Bülow Sand3, Markus Weckmann2,4. 1. Department for Internal Medicine I, University Hospital Schleswig-Holstein Campus Kiel. 2. Airway Research Center North (ARCN), German Center for Lung Research (DZL), Germany. 3. Nordic Bioscience A/S, Herlev, Denmark. 4. Department of Pediatric Pulmonology and Allergology, University Children's Hospital, Lübeck, Germany.
Abstract
PURPOSE OF REVIEW: 'Biomarkers of remodeling' represent a loose collection of features referring to several biological adaptations of the lung to cope with stressing factors. In addition, remodel-'ing' infers a dynamic process that would require a spatiotemporal resolution. This review focuses on different aspects of remodeling in pediatric and adult care. RECENT FINDINGS: This review will cover aspects of pediatric remodeling, adult remodeling and techniques and procedures to adequately assess remodeling across different age spectra. In pediatrics, the onset and first features of remodeling are discussed and the continuation into adolescence is addressed. For adults, this review addresses predominant features of remodeling throughout the adult life span and whether there are currently interventions available to treat or reverse remodeling. SUMMARY: The term 'remodeling' is often referred to via biomarkers that reflect the endstage of a process, although it rather reflects a continuous process starting in childhood and progressing to all age-levels in patients with asthma. Hence, only few biomarkers or surrogates are able to 'capture' its spatiotemporal component, and hardly any are ready for routine use in clinical practice. Given the clinical impact of the remodeling processes, new biomarkers are needed to adequately treat patients with asthma and objectively monitor treatment response beyond symptom control and lung function.
PURPOSE OF REVIEW: 'Biomarkers of remodeling' represent a loose collection of features referring to several biological adaptations of the lung to cope with stressing factors. In addition, remodel-'ing' infers a dynamic process that would require a spatiotemporal resolution. This review focuses on different aspects of remodeling in pediatric and adult care. RECENT FINDINGS: This review will cover aspects of pediatric remodeling, adult remodeling and techniques and procedures to adequately assess remodeling across different age spectra. In pediatrics, the onset and first features of remodeling are discussed and the continuation into adolescence is addressed. For adults, this review addresses predominant features of remodeling throughout the adult life span and whether there are currently interventions available to treat or reverse remodeling. SUMMARY: The term 'remodeling' is often referred to via biomarkers that reflect the endstage of a process, although it rather reflects a continuous process starting in childhood and progressing to all age-levels in patients with asthma. Hence, only few biomarkers or surrogates are able to 'capture' its spatiotemporal component, and hardly any are ready for routine use in clinical practice. Given the clinical impact of the remodeling processes, new biomarkers are needed to adequately treat patients with asthma and objectively monitor treatment response beyond symptom control and lung function.
Authors: Daljeet Singh Dhanjal; Parvarish Sharma; Meenu Mehta; Murtaza M Tambuwala; Parteek Prasher; Keshav R Paudel; Gang Liu; Shakti D Shukla; Philip M Hansbro; Dinesh Kumar Chellappan; Kamal Dua; Saurabh Satija Journal: Future Med Chem Date: 2022-01-12 Impact factor: 3.808
Authors: Sarah Rank Rønnow; Jannie Marie Bülow Sand; Line Mærsk Staunstrup; Thomas Bahmer; Michael Wegmann; Lars Lunding; Janette Burgess; Klaus Rabe; Grith Lykke Sorensen; Oliver Fuchs; Erika V Mutius; Gesine Hansen; Matthias Volkmar Kopp; Morten Karsdal; Diana Julie Leeming; Markus Weckmann Journal: Asthma Res Pract Date: 2022-04-13