Literature DB >> 31648773

[Lymph node management in endometrial cancer].

Clémentine Owen1, Sofiane Bendifallah2, Aude Jayot3, Anna Ilenko3, Alexandra Arfi3, Anne Sophie Boudy3, Sandrine Richard4, Justine Varinot5, Isabelle Thomassin-Naggara5, Marc Bazot6, Émile Daraï2.   

Abstract

In 2018, around 382,100 new cases of endometrial cancer (EC) were reported worldwide, accounting for about 4.4% of all new cases of cancer in women. In France, in 2018, the EC is the first gynecological cancer in incidence and the fourth cancer in women. The rationale for the therapeutic management of EC is based on the estimation of a theoretical risk of recurrence and lymph node metastasis using MRI and preoperative biopsy criteria. However, lymph node status remains the determining factor of adjuvant treatment. In order to reduce the morbidity of lymphadenectomy, the concept of sentinel lymph node biopsy (SLN) has been developed. The SLN technique has evolved in recent years, thanks to the advent of robotics and the creation of fluorescence detection cameras. It has been shown that detection of SLN with Indocyanine Green (ICG) allows for more frequent bilateral migration of 88 to 100% and better detection of pelvic GS in 97% of cases with a decrease in morbidity. Recently, in view of the absence of a therapeutic role of lymph node staging, the operational risks and the delay of adjuvant treatments, in case of pelvic lymph node metastasis on definitive histological examination, the question of secondarily performing paraaortic lymphadenectomy arises. The SLN procedure, extended to all early-stage endometrial cancers, should lead to a major reduction in the use of secondary staging and better adaptation of adjuvant therapy.
Copyright © 2019 Société Française du Cancer. Published by Elsevier Masson SAS. All rights reserved.

Entities:  

Keywords:  Cancer de l’endomètre; Endometrial cancer; Ganglion sentinelle; Lymphadenectomy; Lymphadénectomie; Prognosis; Pronostique; Sentinel lymph node

Year:  2019        PMID: 31648773     DOI: 10.1016/j.bulcan.2019.06.015

Source DB:  PubMed          Journal:  Bull Cancer        ISSN: 0007-4551            Impact factor:   1.276


  2 in total

1.  [Non endometroid endometrial cancer guidelines evaluation: A multicentric retrospective study].

Authors:  Antoine Scattarelli; Albane Poteau; Moutaz Aziz; Marick Lae; Philippe Courville; Maxime Arnaud; Loic Marpeau; Benoit Resch
Journal:  Bull Cancer       Date:  2020-10-06       Impact factor: 1.276

2.  Reconstruction of Immune Microenvironment and Signaling Pathways in Endometrioid Endometrial Adenocarcinoma During Formation of Lymphovascular Space Involvement and Lymph Node Metastasis.

Authors:  Yuan Cheng; Xiaobo Zhang; Zhiqi Wang; Jianliu Wang
Journal:  Front Oncol       Date:  2020-12-09       Impact factor: 6.244

  2 in total

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