M Pascual-Geler1, I Robles-Fernandez2, C Monteagudo3,4, O Lopez-Guarnido5, L Rodrigo5, Y Gálvez-Ontiveros3, J M Cozar1, A Rivas3,4, M J Alvarez-Cubero2,6. 1. Urology Department, University Hospital Virgen de las Nieves, Granada, Spain. 2. GENYO (Pfizer-University of Granada-Andalusian Government Centre for Genomics and Oncological Research), Granada, Spain. 3. Department of Nutrition and Food Science, University of Granada, Granada, Spain. 4. Instituto de Investigación Biosanitaria (ibs. GRANADA), Granada, Spain. 5. Legal Medicine and Toxicology Department, University of Granada, Granada, Spain. 6. Department of Biochemistry & Molecular Biology III - Faculty of Medicine - PTS, University of Granada, Granada, Spain.
Abstract
Purpose: To analyse the relation between antioxidant genotypes and Dietary Antioxidant Quality score (DAQs) effect on prostate cancer (PCa) risk and aggressiveness in a Spanish population. Methods: Men (N = 155 patients and 152 controls) with PSA values >4 ng/ml were enrolled in the project. DAQs were used considering the daily recommended intake for Spanish people (DRI). Genotyping of 5 SNPs rs662 (PON1), rs10432782 (SOD1), rs4880 (SOD2), rs17650792 (GPX1) and rs1001179 (CAT) were included for the analysis. Results: rs17650792 was statistically significant between case and controls subjects. When comparing D´Amico risk, we found that rs662 (CC), rs10432782 (G allele) and rs17650792 (GG) confer a protection. When testing SNP-antioxidant nutrients interactions, we found an intake of vitamin A and rs100179 (T carriers) and selenium and rs17650792 (G carriers) confers a protection of being in low risk classification.Conclusions: We reported by the first time a correlation between rs662 (PON1) and PCa aggressiveness.
Purpose: To analyse the relation between antioxidant genotypes and Dietary Antioxidant Quality score (DAQs) effect on prostate cancer (PCa) risk and aggressiveness in a Spanish population. Methods:Men (N = 155 patients and 152 controls) with PSA values >4 ng/ml were enrolled in the project. DAQs were used considering the daily recommended intake for Spanish people (DRI). Genotyping of 5 SNPs rs662 (PON1), rs10432782 (SOD1), rs4880 (SOD2), rs17650792 (GPX1) and rs1001179 (CAT) were included for the analysis. Results:rs17650792 was statistically significant between case and controls subjects. When comparing D´Amico risk, we found that rs662 (CC), rs10432782 (G allele) and rs17650792 (GG) confer a protection. When testing SNP-antioxidant nutrients interactions, we found an intake of vitamin A and rs100179 (T carriers) and selenium and rs17650792 (G carriers) confers a protection of being in low risk classification.Conclusions: We reported by the first time a correlation between rs662 (PON1) and PCaaggressiveness.
Entities:
Keywords:
Dietary Antioxidant Quality Score; SNPs; oxidative stress; prostate cancer
Authors: Na Tao; Lianhong Li; Qing Chen; Zhongming Sun; Qinglin Yang; Dafang Cao; Xun Zhao; Fangfang Zeng; Jun Liu Journal: Front Public Health Date: 2022-05-13