Haoxiang Jiang1,2,3, Heng Liu1,2, Hairong He4, Jian Yang1,2, Zhe Liu2, Tingting Huang2, Jun Lyu4, Xianjun Li2. 1. The Key Laboratory of Biomedical Information Engineering of the Ministry of Education, Department of Biomedical Engineering, School of Life Science and Technology, Xi'an Jiaotong University, Xi'an, China. 2. Department of Diagnostic Radiology, The First Affiliated Hospital, Xi'an Jiaotong University, Xi'an, China. 3. Department of Diagnostic Radiology, Xi'an Children Hospital, Xi'an, China. 4. Department of Clinical Research Center, The First Affiliated Hospital, Xi'an Jiaotong University, Xi'an, China.
Abstract
BACKGROUND: Assessing motor impairment in spastic cerebral palsy is a key factor in the treatment and rehabilitation of patients. We intend to investigate the correlation between diffusion tensor imaging properties of sensorimotor pathways and motor function in spastic cerebral palsy using meta-analysis, and to determine specific white matter lesions that are closely related to motor dysfunction in spastic cerebral palsy. METHODS: We conducted a literature search of PubMed, Embase, Scopus, and Web of Science databases to identify trials published from January 1999 to January 2019 that had evaluated the correlation between fractional anisotropy and motor function scores in spastic cerebral palsy. Correlation coefficient (r) values were extracted for each study, and the extent of r was quantitatively explored. The r values between fractional anisotropy within different sensorimotor pathways and motor function scores were pooled respectively. RESULTS: Nineteen studies involving 504 children with spastic cerebral palsy, were included. Fractional anisotropy in both sensory and motor pathways significantly correlated with motor function scores. However, compared with the corticospinal tract and thalamic radiation, fractional anisotropy in the posterior limb of the internal capsule correlated more strongly with gross motor function classification system and upper limb motor function (r = -0.71, 95% confidence interval [CI] -0.80 to -0.60; r = 0.73, 95% CI 0.60-0.82, respectively; P < .05). CONCLUSIONS: Fractional anisotropy within the posterior limb of the internal capsule is more closely related to motor dysfunction and can potentially be a biomarker for evaluating the degree of motor impairment in spastic cerebral palsy.
BACKGROUND: Assessing motor impairment in spastic cerebral palsy is a key factor in the treatment and rehabilitation of patients. We intend to investigate the correlation between diffusion tensor imaging properties of sensorimotor pathways and motor function in spastic cerebral palsy using meta-analysis, and to determine specific white matter lesions that are closely related to motor dysfunction in spastic cerebral palsy. METHODS: We conducted a literature search of PubMed, Embase, Scopus, and Web of Science databases to identify trials published from January 1999 to January 2019 that had evaluated the correlation between fractional anisotropy and motor function scores in spastic cerebral palsy. Correlation coefficient (r) values were extracted for each study, and the extent of r was quantitatively explored. The r values between fractional anisotropy within different sensorimotor pathways and motor function scores were pooled respectively. RESULTS: Nineteen studies involving 504 children with spastic cerebral palsy, were included. Fractional anisotropy in both sensory and motor pathways significantly correlated with motor function scores. However, compared with the corticospinal tract and thalamic radiation, fractional anisotropy in the posterior limb of the internal capsule correlated more strongly with gross motor function classification system and upper limb motor function (r = -0.71, 95% confidence interval [CI] -0.80 to -0.60; r = 0.73, 95% CI 0.60-0.82, respectively; P < .05). CONCLUSIONS: Fractional anisotropy within the posterior limb of the internal capsule is more closely related to motor dysfunction and can potentially be a biomarker for evaluating the degree of motor impairment in spastic cerebral palsy.
Authors: Diane L Damiano; James J Pekar; Susumu Mori; Andreia Vasconcellos Faria; X Ye; Elaine Stashinko; Christopher J Stanley; Katharine E Alter; Alec H Hoon; Eric M Chin Journal: Front Rehabil Sci Date: 2022-04-05
Authors: Winnie Wan Yee Tso; Edward Sai Kam Hui; Tatia Mei Chun Lee; Anthony Pak Yin Liu; Patrick Ip; Vince Vardhanabhuti; Kevin King Fai Cheng; Daniel Yee Tak Fong; Dorita Hue Fung Chang; Frederick Ka Wing Ho; Ka Man Yip; Dennis Tak Loi Ku; Daniel Ka Leung Cheuk; Chung Wing Luk; Ming Kong Shing; Lok Kan Leung; Pek Lan Khong; Godfrey Chi-Fung Chan Journal: Front Oncol Date: 2021-05-26 Impact factor: 6.244