Yang Gao1, Jun Chen, Jin Zhang, Lei Sun, Yiping Zhuang. 1. 1Department of Radiology, The Affiliated Cancer Hospital of Nanjing Medical University and Jiangsu Cancer Hospital and Jiangsu Institute of Cancer Research, Nanjing, China.
Abstract
PURPOSE: To retrospectively analyze the factors influencing response, local progression, local progression-free survival (LPFS), and overall survival (OS) in patients with primary non-small cell lung cancer (NSCLC) after computed tomography (CT)-guided radiofrequency ablation (RFA). METHODS: From August 2012 to October 2017, 108 lesions of 108 patients who had undergone CT-guided RFA were analyzed in this study. Patients were followed after RFA continuously. Meanwhile, technical success rate, incomplete ablation rate, local progression, LPFS and OS were assessed. RESULTS: In all patients, 100% technical success rate was achieved. Incomplete ablation rate was 9.26% (10 of 108). Maximum diameter of lesions was associated with incomplete ablation. Maximum diameter of lesions, clinical stage, solitary lesion in the lung and treatments after initial RFA were significantly related to LPFS. Maximum diameter of lesions clinical stage, solitary lesion in the lung, histologic types and treatments after initial RFA were significantly related to OS. CONCLUSIONS: Maximum diameter of lesions ≤3cm, early clinical stage, solitary lesion in the lung and RFA combined with cisplatin and carboplatin chemotherapy and/or tyrosine kinase inhibitors (TKI) all were positive factors of local efficacy and survival after RFA of primary NSCLC.
PURPOSE: To retrospectively analyze the factors influencing response, local progression, local progression-free survival (LPFS), and overall survival (OS) in patients with primary non-small cell lung cancer (NSCLC) after computed tomography (CT)-guided radiofrequency ablation (RFA). METHODS: From August 2012 to October 2017, 108 lesions of 108 patients who had undergone CT-guided RFA were analyzed in this study. Patients were followed after RFA continuously. Meanwhile, technical success rate, incomplete ablation rate, local progression, LPFS and OS were assessed. RESULTS: In all patients, 100% technical success rate was achieved. Incomplete ablation rate was 9.26% (10 of 108). Maximum diameter of lesions was associated with incomplete ablation. Maximum diameter of lesions, clinical stage, solitary lesion in the lung and treatments after initial RFA were significantly related to LPFS. Maximum diameter of lesions clinical stage, solitary lesion in the lung, histologic types and treatments after initial RFA were significantly related to OS. CONCLUSIONS: Maximum diameter of lesions ≤3cm, early clinical stage, solitary lesion in the lung and RFA combined with cisplatin and carboplatin chemotherapy and/or tyrosine kinase inhibitors (TKI) all were positive factors of local efficacy and survival after RFA of primary NSCLC.
Authors: Stefano Giusto Picchi; Giulia Lassandro; Andrea Bianco; Andrea Coppola; Anna Maria Ierardi; Umberto G Rossi; Francesco Lassandro Journal: Med Oncol Date: 2020-03-27 Impact factor: 3.064
Authors: Angel Cilleruelo-Ramos; Esther Cladellas-Gutiérrez; Carolina de la Pinta; Laura Quintana-Cortés; Paloma Sosa-Fajardo; Felipe Couñago; Xabier Mielgo-Rubio; Juan Carlos Trujillo-Reyes Journal: World J Clin Oncol Date: 2021-12-24