Literature DB >> 31646526

Review: Structure and Activation Mechanisms of CRAC Channels.

Carmen Butorac1, Adéla Krizova1, Isabella Derler2.   

Abstract

Ca2+ release activated Ca2+ (CRAC) channels represent a primary pathway for Ca2+ to enter non-excitable cells. The two key players in this process are the stromal interaction molecule (STIM), a Ca2+ sensor embedded in the membrane of the endoplasmic reticulum, and Orai, a highly Ca2+ selective ion channel located in the plasma membrane. Upon depletion of the internal Ca2+ stores, STIM is activated, oligomerizes, couples to and activates Orai. This review provides an overview of novel findings about the CRAC channel activation mechanisms, structure and gating. In addition, it highlights, among diverse STIM and Orai mutants, also the disease-related mutants and their implications.

Entities:  

Keywords:  CRAC channel; Calcium; Electrophysiology; FRET; Gain-of-function mutants; Orai gating; Orai1; STIM-Orai interaction; STIM1; Structural resolution

Mesh：

Substances：

Year:  2020        PMID： 31646526     DOI： 10.1007/978-3-030-12457-1_23

Source DB:  PubMed          Journal:  Adv Exp Med Biol        ISSN： 0065-2598            Impact factor:   2.622


  9 in total

Review 1.  Store-Operated Calcium Entry and Its Implications in Cancer Stem Cells.

Authors:  Isaac Jardin; Jose J Lopez; Jose Sanchez-Collado; Luis J Gomez; Gines M Salido; Juan A Rosado
Journal:  Cells       Date:  2022-04-13       Impact factor: 7.666

Review 2.  The Orai Pore Opening Mechanism.

Authors:  Adéla Tiffner; Lena Maltan; Sarah Weiß; Isabella Derler
Journal:  Int J Mol Sci       Date:  2021-01-07       Impact factor: 5.923

3.  Transmembrane Domain 3 (TM3) Governs Orai1 and Orai3 Pore Opening in an Isoform-Specific Manner.

Authors:  Adéla Tiffner; Lena Maltan; Marc Fahrner; Matthias Sallinger; Sarah Weiß; Herwig Grabmayr; Carmen Höglinger; Isabella Derler
Journal:  Front Cell Dev Biol       Date:  2021-02-11

Review 4.  Molecular Choreography and Structure of Ca2+ Release-Activated Ca2+ (CRAC) and KCa2+ Channels and Their Relevance in Disease with Special Focus on Cancer.

Authors:  Adéla Tiffner; Isabella Derler
Journal:  Membranes (Basel)       Date:  2020-12-15

5.  Defects in the STIM1 SOARα2 domain affect multiple steps in the CRAC channel activation cascade.

Authors:  Carmen Höglinger; Herwig Grabmayr; Lena Maltan; Ferdinand Horvath; Heinrich Krobath; Martin Muik; Adela Tiffner; Thomas Renger; Christoph Romanin; Marc Fahrner; Isabella Derler
Journal:  Cell Mol Life Sci       Date:  2021-09-08       Impact factor: 9.261

6.  Ca2+ signaling driving pacemaker activity in submucosal interstitial cells of Cajal in the murine colon.

Authors:  Salah A Baker; Wesley A Leigh; Guillermo Del Valle; Inigo F De Yturriaga; Sean M Ward; Caroline A Cobine; Bernard T Drumm; Kenton M Sanders
Journal:  Elife       Date:  2021-01-05       Impact factor: 8.140

7.  Orai1 Boosts SK3 Channel Activation.

Authors:  Adéla Tiffner; Valentina Hopl; Romana Schober; Matthias Sallinger; Herwig Grabmayr; Carmen Höglinger; Marc Fahrner; Victoria Lunz; Lena Maltan; Irene Frischauf; Denis Krivic; Rajesh Bhardwaj; Rainer Schindl; Matthias A Hediger; Isabella Derler
Journal:  Cancers (Basel)       Date:  2021-12-17       Impact factor: 6.575

Review 8.  Deciphering Molecular Mechanisms and Intervening in Physiological and Pathophysiological Processes of Ca2+ Signaling Mechanisms Using Optogenetic Tools.

Authors:  Lena Maltan; Hadil Najjar; Adéla Tiffner; Isabella Derler
Journal:  Cells       Date:  2021-11-28       Impact factor: 6.600

Review 9.  The Role of Lipids in CRAC Channel Function.

Authors:  Lena Maltan; Ana-Marija Andova; Isabella Derler
Journal:  Biomolecules       Date:  2022-02-23
  9 in total

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