Daniela Pițigoi1, Maria Nițescu2, Anca Streinu-Cercel3, Rodica Bacruban4, Alina Elena Ivanciuc5, Mihaela Lazăr6, Carmen Maria Cherciu7, Maria Dorina Crăciun8, Victoria Aramă9, Adrian Streinu-Cercel9, Oana Săndulescu3. 1. MD, PhD, Associate Professor, Department of Epidemiology, Faculty of Medicine, Carol Davila University of Medicine and Pharmacy, Bucharest, National Institute for Infectious Diseases "Prof. Dr. Matei Balș", No. 1 Dr. Calistrat Grozovici street, Bucharest 021105, Romania. 2. MD, PhD, Associate Professor, Department of Hygiene and Medical Ecology, Faculty of Medicine, Carol Davila University of Medicine and Pharmacy, Bucharest, National Institute for Infectious Diseases "Prof. Dr. Matei Balș", No. 1 Dr. Calistrat Grozovici street, Bucharest 021105, Romania. 3. MD, PhD, Associate Professor, Department of Infectious Diseases I, Faculty of Medicine, Carol Davila University of Medicine and Pharmacy, Bucharest, National Institute for Infectious Diseases "Prof. Dr. Matei Balș", No. 1 Dr. Calistrat Grozovici street, Bucharest 021105, Romania. 4. MD, National Institute for Infectious Diseases "Prof. Dr. Matei Balș", No. 1 Dr. Calistrat Grozovici street, Bucharest 021105, Romania. 5. Biologist, PhD student, National Institute for Medico-Military Research Cantacuzino, National Influenza Centre, No. 103 Splaiul Independenței, Bucharest 050096, Romania. 6. Biologist, PhD, National Institute for Medico-Military Research Cantacuzino, National Influenza Centre, No. 103 Splaiul Independenței, Bucharest 050096, Romania. 7. Biochemist, National Institute for Medico-Military Research Cantacuzino, National Influenza Centre, No. 103 Splaiul Independenței, Bucharest 050096, Romania. 8. MD, PhD, Assistant Lecturer, Department of Epidemiology, Faculty of Medicine, Carol Davila University of Medicine and Pharmacy, Bucharest, Grigore Alexandrescu Clinical Children's Emergency Hospital, No. 30-32 Iancu de Hunedoara boulevard, Bucharest 011743, Romania. 9. MD, PhD, Professor, Department of Infectious Diseases I, Faculty of Medicine, Carol Davila University of Medicine and Pharmacy, Bucharest, National Institute for Infectious Diseases "Prof. Dr. Matei Balș", No. 1 Dr. Calistrat Grozovici street, Bucharest 021105, Romania.
Abstract
INTRODUCTION: Patients with diabetes may be at a higher risk of developing complicated influenza. We report the characteristics of influenza in hospitalized elderly patients with and without diabetes, in three consecutive influenza seasons. METHODS: The study included patients admitted for severe acute respiratory infection (SARI) in the National Institute for Infectious Diseases "Prof. Dr. Matei Balș", Bucharest, during a three-year active epidemiological surveillance study (2015/16, 2016/17, 2017/18), in the I-MOVE+ hospital network. RESULTS: A total of 349 patients were tested by PCR over the duration of the study. The percentage of patients with diabetes was comparable throughout the seasons: 34.7%, 28.3% and 30.4% (p=0.587). Influenza A was the main viral type circulating in 2015/16 and 2016/17 (100% and 97.6%) in our study population, while in 2017/18, B viruses predominated (90.0%). Diabetics presented a higher median number of comorbidities (3 vs. 2) p<0.001, and two-fold higher odds of also associating obesity (OR=2.1, 95%CI:1.3-3.4, p=0.003), compared to those without diabetes. Diabetics also tested positive for influenza more often (p=0.296). Only 6 patients with diabetes (5.4%) from our study had been vaccinated against influenza, and most (n=4) of those who had been vaccinated tested negative for influenza. CONCLUSIONS: Our study is the first to describe the circulation of influenza viral types in elderly diabetic patients hospitalized for SARI. The results reinforce the national and international recommendation to vaccinate against influenza all patients with diabetes. GERMS.
INTRODUCTION: Patients with diabetes may be at a higher risk of developing complicated influenza. We report the characteristics of influenza in hospitalized elderly patients with and without diabetes, in three consecutive influenza seasons. METHODS: The study included patients admitted for severe acute respiratory infection (SARI) in the National Institute for Infectious Diseases "Prof. Dr. Matei Balș", Bucharest, during a three-year active epidemiological surveillance study (2015/16, 2016/17, 2017/18), in the I-MOVE+ hospital network. RESULTS: A total of 349 patients were tested by PCR over the duration of the study. The percentage of patients with diabetes was comparable throughout the seasons: 34.7%, 28.3% and 30.4% (p=0.587). Influenza A was the main viral type circulating in 2015/16 and 2016/17 (100% and 97.6%) in our study population, while in 2017/18, B viruses predominated (90.0%). Diabetics presented a higher median number of comorbidities (3 vs. 2) p<0.001, and two-fold higher odds of also associating obesity (OR=2.1, 95%CI:1.3-3.4, p=0.003), compared to those without diabetes. Diabetics also tested positive for influenza more often (p=0.296). Only 6 patients with diabetes (5.4%) from our study had been vaccinated against influenza, and most (n=4) of those who had been vaccinated tested negative for influenza. CONCLUSIONS: Our study is the first to describe the circulation of influenza viral types in elderly diabetic patients hospitalized for SARI. The results reinforce the national and international recommendation to vaccinate against influenza all patients with diabetes. GERMS.
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Authors: Daniela Pițigoi; Anca Streinu-Cercel; Alina Elena Ivanciuc; Mihaela Lazãr; Carmen Maria Cherciu; Maria Elena Mihai; Maria Nițescu; Victoria Aramă; Maria Dorina Crăciun; Adrian Streinu-Cercel; Oana Săndulescu Journal: Influenza Other Respir Viruses Date: 2020-05-15 Impact factor: 4.380