Literature DB >> 31646137

A Multidisciplinary Approach to the Management of Severe Purpura Fulminans in a Burn Center: A Case Series.

Mohammed Asif1, Luis Quiroga1, Tomer Lagziel2, Seth B Ladd3, Julie Caffrey1.   

Abstract

Purpura fulminans is a life-threatening hematological emergency characterized by skin necrosis and disseminated intravascular coagulation requiring rapid diagnosis and treatment. We present a case series of patients with severe purpura fulminans who were managed via a multidisciplinary approach at a regional burn center. We report the burn unit perspective which includes current intensive care guidelines with early surgical intervention, in addition to a review of the pathology and clinical features of the disease. Proper wound management and expeditious surgical evaluation can help reduce the mortality and minimize amputations. Early referral to a burn center with a multidisciplinary team is recommended for the best outcomes in these patients.
Copyright © 2019, Asif et al.

Entities:  

Keywords:  disseminated intravascular coagulation; purpura fulminans; sepsis

Year:  2019        PMID: 31646137      PMCID: PMC6805038          DOI: 10.7759/cureus.5478

Source DB:  PubMed          Journal:  Cureus        ISSN: 2168-8184


  15 in total

Review 1.  Purpura fulminans in sepsis.

Authors:  Alex P Betrosian; Tom Berlet; Banwari Agarwal
Journal:  Am J Med Sci       Date:  2006-12       Impact factor: 2.378

2.  The burn unit as a resource for the management of acute nonburn conditions in children.

Authors:  R L Sheridan; S E Briggs; J P Remensnyder; S W Gagnon; D P Doody; D P Ryan; R G Tompkins
Journal:  J Burn Care Rehabil       Date:  1995 Jan-Feb

Review 3.  Pathogenesis of meningococcal purpura fulminans.

Authors:  Hervé Lécuyer; Delphine Borgel; Xavier Nassif; Mathieu Coureuil
Journal:  Pathog Dis       Date:  2017-04-01       Impact factor: 3.166

4.  Management strategy in purpura fulminans with multiple organ failure in children.

Authors:  R L Sheridan; S E Briggs; J P Remensnyder; R G Tompkins
Journal:  Burns       Date:  1996-02       Impact factor: 2.744

Review 5.  Meningococcal sepsis and purpura fulminans: the surgical perspective.

Authors:  Marvin E Morris; John G Maijub; Sarah K Walker; Glenn P Gardner; Riley G Jones
Journal:  Postgrad Med J       Date:  2013-02-06       Impact factor: 2.401

6.  Acquired deficiencies of protein S. Protein S activity during oral anticoagulation, in liver disease, and in disseminated intravascular coagulation.

Authors:  A D'Angelo; S Vigano-D'Angelo; C T Esmon; P C Comp
Journal:  J Clin Invest       Date:  1988-05       Impact factor: 14.808

7.  Protein C and protein S deficiency - practical diagnostic issues.

Authors:  Ewa Wypasek; Anetta Undas
Journal:  Adv Clin Exp Med       Date:  2013 Jul-Aug       Impact factor: 1.727

Review 8.  Pathogenesis of meningococcemia.

Authors:  Mathieu Coureuil; Olivier Join-Lambert; Hervé Lécuyer; Sandrine Bourdoulous; Stefano Marullo; Xavier Nassif
Journal:  Cold Spring Harb Perspect Med       Date:  2013-06-01       Impact factor: 6.915

9.  Impact of time to antibiotics on survival in patients with severe sepsis or septic shock in whom early goal-directed therapy was initiated in the emergency department.

Authors:  David F Gaieski; Mark E Mikkelsen; Roger A Band; Jesse M Pines; Richard Massone; Frances F Furia; Frances S Shofer; Munish Goyal
Journal:  Crit Care Med       Date:  2010-04       Impact factor: 7.598

Review 10.  The differential diagnosis of purpura from a morphologic perspective.

Authors:  W W Piette
Journal:  Adv Dermatol       Date:  1994
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  2 in total

1.  Purpura Fulminans in a Patient With Septic Shock due to Escherichia coli Bacteremia With Emphysematous Pyelitis.

Authors:  Maria Del Mar Morales Hernandez; Michael Carranza; Bijal Patel; Joshua Calvert; Ghania Masri
Journal:  Cureus       Date:  2021-02-09

Review 2.  Septic Shock and Purpura Fulminans Due to Streptococcus pneumoniae Bacteremia in an Unvaccinated Immunocompetent Adult: Case Report and Review.

Authors:  Nikola Djurdjevic; Pahnwat Tonya Taweesedt; Margaret Paulson; Abigail LaNou; Milan Radovanovic; Janki N Patel; Mladjen Veselinovic; Wendy R McDermott; Igor Dumic
Journal:  Am J Case Rep       Date:  2020-06-09
  2 in total

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