| Literature DB >> 31646026 |
Xiaojing Song1, Shuyou Wang1, Chong Zhao2, Weibo Zhang1, Guangjun Wang1, Shuyong Jia1.
Abstract
The visual evaluation of liver function (LF) has always been a hot topic in research on liver diseases. In vivo fluorescence imaging (IVFI) of the Cy5.5-galactosylated polylysine (Cy5.5-GP) probe targeting asialoglycoprotein receptor (ASGPR), for evaluating LF in chronic alcoholic liver injury (cALI) mice was investigated in this study. The decrease of fluorescence signals in the livers showed a biological relationship with the liver ASGPR expression, histology, and serum marker levels of LF in cALI mice. The targeted IVFI of ASGPR as a novel method can intuitively and noninvasively display the characteristics of liver's ASGPR level to provide a reference for evaluating LF.Entities:
Year: 2019 PMID: 31646026 PMCID: PMC6788595 DOI: 10.1364/BOE.10.005015
Source DB: PubMed Journal: Biomed Opt Express ISSN: 2156-7085 Impact factor: 3.732