G Damiani1,2,3,4, N L Bragazzi4,5,6,7, S Garbarino7, V K Chattu8,9, C M Shapiro8,9, A Pacifico10, P Malagoli11, P D M Pigatto1,2, R R Z Conic12, D Tiodorovic13, A Watad14,15, M Adawi16. 1. Clinical Dermatology, IRCCS Istituto Ortopedico Galeazzi, Milan, Italy. 2. Department of Biomedical, Surgical and Dental Sciences, University of Milan, Milan, Italy. 3. Department of Dermatology, Case Western Reserve University, Cleveland, OH, USA. 4. Young Dermatologists Italian Network, Centro Studi GISED, Bergamo, Italy. 5. Postgraduate School of Public Health, Department of Health Sciences, University of Genoa, Genoa, Italy. 6. Laboratory for Industrial and Applied Mathematics (LIAM), Department of Mathematics and Statistics, York University, Toronto, Ontario, Canada. 7. Department of Neuroscience, Rehabilitation, Ophthalmology, Genetics and Maternal/Child Sciences (DINOGMI), University of Genoa, Genoa, Italy. 8. Department of Psychiatry, University of Toronto, Toronto, Ontario, Canada. 9. Youthdale Child and Adolescent Sleep Centre, Toronto, Ontario, Canada. 10. San Gallicano Dermatological Institute, IRCCS, Rome, Italy. 11. Dermatology UnitAzienda Ospedaliera San Donato Milanese, Milan, Italy. 12. Department of Surgery, University of Maryland, Baltimore, MD, USA. 13. Dermatology Clinic, Medical Faculty, Nis University, Nis, Serbia. 14. Department of Medicine B and Zabludowicz Center for Autoimmune Diseases, Sheba Medical Center, Tel-Hashomer, Ramat-Gan, Israel. 15. Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel. 16. Padeh and Ziv Hospitals, Azrieli Faculty of Medicine, Bar-Ilan University, Ramat Gan, Israel.
Abstract
Background: Jet-lag may affect air-travelers crossing at least two time-zones and has several health-care implications. It occurs when the human biological rhythms are out of synch with respect to the day-night cycle at the country destination. Its effect in psoriasis is missing. We aimed to evaluate the effect of Jet-lag in psoriatic patients' management. Methods: This is a prospective observational study that enrolled psoriatic patients that underwent a flight: patients who experienced jet-lag were compared to patients who did not experience jet-lag. Before the flight, a dermatologist recorded clinical and demographical data with particular attention to Psoriasis Area Severity Index (PASI) and Disease Activity in Psoriatic Arthritis (DAPSA). Patients performed Self-Administered Psoriasis Area Severity Index (SAPASI), the Dermatology Life Quality Index (DLQI) and the pruritus Visual Analog Scale (VAS) scores. After the flight, patients completed the SAPASI, DLQI and pruritus-VAS scores. Results: The sample recruited comprised of 70 psoriatic patients aged 42.4 ± 9.7 years (median 42.5 years). Thirty (42.9%) were males, mean BMI was 25.5 ± 2.2 kg/m2. Average disease duration was 15.2 ± 7.1 years, and 20 (28.6%) subjects had developed PsA. Average hours of flight were 5.4 ± 3.5 (median 3.5 h), with 34 (48.6%) subjects reporting jet-lag. At the multivariate regression analysis, the change in the SAPASI score resulted correlated with jet-lag (regression coefficient 1.63, p = .0092), as well the change in the DLQI score (regression coefficient = 1.73, p = .0009), but no change on the pruritus VAS scale was found. Conclusions: The present study suggests that jet-lag may influence disease severity and DLQI scores, but not itch in psoriatic patients.
Background: Jet-lag may affect air-travelers crossing at least two time-zones and has several health-care implications. It occurs when the human biological rhythms are out of synch with respect to the day-night cycle at the country destination. Its effect in psoriasis is missing. We aimed to evaluate the effect of Jet-lag in psoriaticpatients' management. Methods: This is a prospective observational study that enrolled psoriaticpatients that underwent a flight: patients who experienced jet-lag were compared to patients who did not experience jet-lag. Before the flight, a dermatologist recorded clinical and demographical data with particular attention to Psoriasis Area Severity Index (PASI) and Disease Activity in Psoriatic Arthritis (DAPSA). Patients performed Self-Administered Psoriasis Area Severity Index (SAPASI), the Dermatology Life Quality Index (DLQI) and the pruritus Visual Analog Scale (VAS) scores. After the flight, patients completed the SAPASI, DLQI and pruritus-VAS scores. Results: The sample recruited comprised of 70 psoriaticpatients aged 42.4 ± 9.7 years (median 42.5 years). Thirty (42.9%) were males, mean BMI was 25.5 ± 2.2 kg/m2. Average disease duration was 15.2 ± 7.1 years, and 20 (28.6%) subjects had developed PsA. Average hours of flight were 5.4 ± 3.5 (median 3.5 h), with 34 (48.6%) subjects reporting jet-lag. At the multivariate regression analysis, the change in the SAPASI score resulted correlated with jet-lag (regression coefficient 1.63, p = .0092), as well the change in the DLQI score (regression coefficient = 1.73, p = .0009), but no change on the pruritus VAS scale was found. Conclusions: The present study suggests that jet-lag may influence disease severity and DLQI scores, but not itch in psoriaticpatients.
Authors: Pedram Razavi; Elizabeth E Devore; Archna Bajaj; Steven W Lockley; Mariana G Figueiro; Vincent Ricchiuti; W James Gauderman; Susan E Hankinson; Walter C Willett; Eva S Schernhammer Journal: Cancer Epidemiol Biomarkers Prev Date: 2019-05-29 Impact factor: 4.254
Authors: C E M Griffiths; J M van der Walt; D M Ashcroft; C Flohr; L Naldi; T Nijsten; M Augustin Journal: Br J Dermatol Date: 2017-05-28 Impact factor: 9.302
Authors: Farah Asa'ad; Marco Fiore; Aniello Alfieri; Paolo Daniele Maria Pigatto; Chiara Franchi; Emilio Berti; Carlo Maiorana; Giovanni Damiani Journal: Biomed Res Int Date: 2018-05-20 Impact factor: 3.411
Authors: Giovanni Damiani; Abdulla Watad; Charlie Bridgewood; Paolo Daniele Maria Pigatto; Alessia Pacifico; Piergiorgio Malagoli; Nicola Luigi Bragazzi; Mohammad Adawi Journal: Nutrients Date: 2019-01-27 Impact factor: 5.717
Authors: Justyna M Wierzbicka; Anna Piotrowska; Dorota Purzycka-Bohdan; Anna Olszewska; Joanna I Nowak; Aneta Szczerkowska-Dobosz; Bogusław Nedoszytko; Roman J Nowicki; Michał A Żmijewski Journal: Int J Mol Sci Date: 2021-11-29 Impact factor: 5.923