Marta Díaz1,2, Laura Campderrós1,3,4, Mariana P Guimaraes3, Abel López-Bermejo5,6, Francis de Zegher7,8, Francesc Villarroya1,3,4, Lourdes Ibáñez9,10. 1. Pediatric Research Institute Sant Joan de Déu, University of Barcelona, 08950, Esplugues, Barcelona, Spain. 2. Centro de Investigación Biomédica en Red de Diabetes y Enfermedades Metabólicas Asociadas (CIBERDEM), Health Institute Carlos III, Madrid, Spain. 3. Biochemistry and Molecular Biomedicine Department, Biomedicine Institute, University of Barcelona, 08028, Barcelona, Spain. 4. Network Biomedical Research Center of Physiopathology of Obesity and Nutrition (CIBEROBN), Health Institute Carlos III, 28029, Madrid, Spain. 5. Department of Pediatrics, Dr. Josep Trueta Hospital, 17007, Girona, Spain. 6. Girona Institute for Biomedical Research, Dr. Josep Trueta Hospital, 17007, Girona, Spain. 7. Pediatric & Adolescent Endocrinology, University Hospital Gasthuisberg, 3000, Leuven, Belgium. 8. Department of Development & Regeneration, University of Leuven, 3000, Leuven, Belgium. 9. Pediatric Research Institute Sant Joan de Déu, University of Barcelona, 08950, Esplugues, Barcelona, Spain. libanez@sjdhospitalbarcelona.org. 10. Centro de Investigación Biomédica en Red de Diabetes y Enfermedades Metabólicas Asociadas (CIBERDEM), Health Institute Carlos III, Madrid, Spain. libanez@sjdhospitalbarcelona.org.
Abstract
BACKGROUND: Growth-and-differentiation-factor-15 (GDF15) is a regulator of energy homeostasis. To determine the relationship between circulating GDF15 and parameters of metabolic health, we assessed longitudinally GDF15 concentrations in infants born either appropriate- (AGA) or small-for-gestational-age (SGA), the latter population known to be at risk for metabolic alterations, particularly after a rapid postnatal catch-up in weight. METHODS: The study cohort consisted of 103 infants (70 AGA and 33 SGA). Assessments included body length, weight, and ponderal index (PI); fasting glucose, insulin, IGF-I, high-molecular-weight adiponectin, GDF15; and body composition (by absorptiometry) at birth, and at age 4, 12 and 24 months. RESULTS: GDF15 levels at birth were significantly higher than those at each subsequent time point and were similar in AGA and SGA subjects. GDF15 concentrations dropped at age 4 months, more substantially in SGA infants, and continued to decline in both subgroups reaching adult concentrations by age 24 months. GDF15 levels correlated inversely with the changes in PI, IGF-I and body fat throughout follow-up. CONCLUSIONS: Early life is associated with supra-adult concentrations of GDF15. The lower levels of GDF15 in SGA subjects may be an adaptive mechanism to promote catch-up in weight and might increase the risk for obesity later in life.
BACKGROUND:Growth-and-differentiation-factor-15 (GDF15) is a regulator of energy homeostasis. To determine the relationship between circulating GDF15 and parameters of metabolic health, we assessed longitudinally GDF15 concentrations in infants born either appropriate- (AGA) or small-for-gestational-age (SGA), the latter population known to be at risk for metabolic alterations, particularly after a rapid postnatal catch-up in weight. METHODS: The study cohort consisted of 103 infants (70 AGA and 33 SGA). Assessments included body length, weight, and ponderal index (PI); fasting glucose, insulin, IGF-I, high-molecular-weight adiponectin, GDF15; and body composition (by absorptiometry) at birth, and at age 4, 12 and 24 months. RESULTS:GDF15 levels at birth were significantly higher than those at each subsequent time point and were similar in AGA and SGA subjects. GDF15 concentrations dropped at age 4 months, more substantially in SGA infants, and continued to decline in both subgroups reaching adult concentrations by age 24 months. GDF15 levels correlated inversely with the changes in PI, IGF-I and body fat throughout follow-up. CONCLUSIONS: Early life is associated with supra-adult concentrations of GDF15. The lower levels of GDF15 in SGA subjects may be an adaptive mechanism to promote catch-up in weight and might increase the risk for obesity later in life.
Authors: A G Moore; D A Brown; W D Fairlie; A R Bauskin; P K Brown; M L Munier; P K Russell; L A Salamonsen; E M Wallace; S N Breit Journal: J Clin Endocrinol Metab Date: 2000-12 Impact factor: 5.958
Authors: S A Yuca; E A Cimbek; Y Şen; O Güvenç; H Vatansev; F Buğrul; F Gün; B Oran Journal: Exp Clin Endocrinol Diabetes Date: 2016-10-17 Impact factor: 2.949
Authors: Francis de Zegher; Marta Díaz; Joan Villarroya; Montserrat Cairó; Abel López-Bermejo; Francesc Villarroya; Lourdes Ibáñez Journal: Sci Rep Date: 2021-03-29 Impact factor: 4.379