Jacqueline Mills1, Wendy Kuohung. 1. Department of Obstetrics and Gynecology, Boston Medical Center, Boston, Massachusetts, USA.
Abstract
PURPOSE OF REVIEW: In recent years, new studies have investigated the role and influence of sleep on female fertility and early pregnancy outcomes, providing a growing body of knowledge demonstrating how regulation by sleep of hormones are important to reproduction, and how disruptions in sleep, circadian rhythms, and genes regulating circadian rhythmicity can negatively impact fertility and early pregnancy outcomes. This review aims to summarize the most recent research on the relationship among circadian rhythms, fertility, and early pregnancy outcomes in women, and to explore possible fertility interventions. RECENT FINDINGS: Recent studies have found altered levels of FSH, LH, and prolactin with sleep disturbance or circadian dysrhythmia. Disruption of circadian rhythms in the form of shift work, jet lag, and daylight savings time changes have been associated with poorer fertility and early pregnancy outcomes. Alterations in the expression of circadian rhythm-regulating circadian locomotor output cycles kaput (CLOCK) genes have been associated with decreased fertility and increased rates of miscarriage. SUMMARY: Overall, undisrupted sleep and circadian rhythmicity appear to optimize fertility and early pregnancy outcomes and may play an important role in the success of fertility treatment.
PURPOSE OF REVIEW: In recent years, new studies have investigated the role and influence of sleep on female fertility and early pregnancy outcomes, providing a growing body of knowledge demonstrating how regulation by sleep of hormones are important to reproduction, and how disruptions in sleep, circadian rhythms, and genes regulating circadian rhythmicity can negatively impact fertility and early pregnancy outcomes. This review aims to summarize the most recent research on the relationship among circadian rhythms, fertility, and early pregnancy outcomes in women, and to explore possible fertility interventions. RECENT FINDINGS: Recent studies have found altered levels of FSH, LH, and prolactin with sleep disturbance or circadian dysrhythmia. Disruption of circadian rhythms in the form of shift work, jet lag, and daylight savings time changes have been associated with poorer fertility and early pregnancy outcomes. Alterations in the expression of circadian rhythm-regulating circadian locomotor output cycles kaput (CLOCK) genes have been associated with decreased fertility and increased rates of miscarriage. SUMMARY: Overall, undisrupted sleep and circadian rhythmicity appear to optimize fertility and early pregnancy outcomes and may play an important role in the success of fertility treatment.
Authors: Galit L Dunietz; Giancarlo Vanini; Carol Shannon; Louise M O'Brien; Ronald D Chervin Journal: Sleep Med Rev Date: 2020-03-17 Impact factor: 11.609
Authors: Chawanont Pimolsri; Xiru Lyu; Cathy Goldstein; Chelsea N Fortin; Sunni L Mumford; Yolanda R Smith; Michael S Lanham; Louise M O'Brien; Galit Levi Dunietz Journal: J Assist Reprod Genet Date: 2021-08-10 Impact factor: 3.357
Authors: Francesca Sciarra; Edoardo Franceschini; Federica Campolo; Daniele Gianfrilli; Francesco Pallotti; Donatella Paoli; Andrea M Isidori; Mary Anna Venneri Journal: Int J Mol Sci Date: 2020-05-30 Impact factor: 5.923
Authors: Rosaria Cappadona; Sara Puzzarini; Vanessa Farinelli; Piergiorgio Iannone; Alfredo De Giorgi; Emanuele Di Simone; Roberto Manfredini; Rosita Verteramo; Pantaleo Greco; María Aurora Rodríguez Borrego; Fabio Fabbian; Pablo Jesús López Soto Journal: Int J Environ Res Public Health Date: 2020-11-03 Impact factor: 3.390