Yanhua Zhou1, Yanlin Zhang2, Haiying Zhao1, Xuan Cui3, Yongqiu Wei1, Yongdong Wu1, Shutian Zhang1, Ye Zong4. 1. Department of Gastroenterology, Beijing Friendship Hospital, Capital Medical University, Beijing, 100050, China. 2. Department of Pathology, Beijing Friendship Hospital, Capital Medical University, Beijing, 100050, China. 3. Department of Gastroenterology, People's Hospital of Dongcheng, Beijing, China. 4. Department of Gastroenterology, Beijing Friendship Hospital, Capital Medical University, Beijing, 100050, China. zongye20171008@sina.com.
Abstract
INTRODUCTION: Epstein-Barr virus (EBV)-associated lymphoproliferative diseases (LPD) with digestive tract involvement in immunocompetent patients is rather rare. Since the symptoms of EBV-associated LPD involving the gastrointestinal tract in immunocompetent patients are similar to those of inflammatory bowel disease (IBD), most patients are initially misdiagnosed. CASE PRESENTATION: In this paper, we present two cases of EBV-associated T cell LPD involving the colon in immunocompetent patients and review the relevant literature. CONCLUSION: EBV serological testing may help in detecting this disease, and our findings suggest that histopathological evidence of EBV, such as the Epstein-Barr encoding region, is very important to establish the diagnosis.
INTRODUCTION:Epstein-Barr virus (EBV)-associated lymphoproliferative diseases (LPD) with digestive tract involvement in immunocompetent patients is rather rare. Since the symptoms of EBV-associated LPD involving the gastrointestinal tract in immunocompetent patients are similar to those of inflammatory bowel disease (IBD), most patients are initially misdiagnosed. CASE PRESENTATION: In this paper, we present two cases of EBV-associated T cell LPD involving the colon in immunocompetent patients and review the relevant literature. CONCLUSION:EBV serological testing may help in detecting this disease, and our findings suggest that histopathological evidence of EBV, such as the Epstein-Barr encoding region, is very important to establish the diagnosis.
Authors: S Sazuka; Y Takahashi; T Kawaguchi; T Sato; T Nakagawa; Y Furuya; M Saito; K Saito; T Katsuno; C Nakaseko; O Yokosuka Journal: Endoscopy Date: 2012-03-06 Impact factor: 10.093