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Literature DB >> 31640967

[Effect of cinobufagin on transient outward potassium current in dorsal root ganglion cells of rats with cancer-induced bone pain].

Shiyu Zhu¹, Dan Liu¹, Wei Hu¹, Hongwei Yang¹.

Abstract

OBJECTIVE: To observe the effect of cinobufagin on transient outward potassium current (IA) in rat dorsal root ganglion cells of cancer-induced bone pain (CIBP) and explore the possible analgesic mechanism of cinobufagin.
METHODS: Whole cell patch clamp technique was used to examine the effect of cionbufagin on IA in acutely isolated dorsal root ganglion (DRG) cells from normal SD rats and rats with bone cancer pain.
RESULTS: The DRG cells from rats with CIBP showed obviously decreased IA current density, an activation curve shift to the right, and an inactivation curve shift to the left. Cinobufagin treatment significantly increased the IA current density and reversed the changes in the activation and inactivation curves in the DRG cells.
CONCLUSIONS: IA current is decreased in DRG neurons from rats with CIBP. Cinobufagin can regulate the activation and inactivation of IA current in the DRG cells, which may be related to its analgesic mechanism.

Entities: Chemical

Keywords: analgesic effect; cancer-induced bone pain; cinobufagin; dorsal root ganglion; transient outward potassium current

Mesh：

Substances：

Year: 2019 PMID： 31640967 PMCID： PMC6881743 DOI： 10.12122/j.issn.1673-4254.2019.09.12

Source DB: PubMed Journal: Nan Fang Yi Ke Da Xue Xue Bao ISSN： 1673-4254

29 in total

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Review 3. Sodium channels in normal and pathological pain.

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Journal: Annu Rev Neurosci Date: 2010 Impact factor: 12.449

4. The Distributions of Voltage-Gated K⁺ current Subtypes in Different Cell Sizes from Adult Mouse Dorsal Root Ganglia.

Authors: Anqi Sheng; Jiangru Hong; Lulu Zhang; Yan Zhang; Guangqin Zhang
Journal: J Membr Biol Date: 2018-03-29 Impact factor: 1.843

5. K⁺ Channel Modulatory Subunits KChIP and DPP Participate in Kv4-Mediated Mechanical Pain Control.

Authors: Yen-Ling Kuo; Jen-Kun Cheng; Wen-Hsien Hou; Yu-Cheng Chang; Po-Hao Du; Jhao-Jun Jian; Ruey-Horng Rau; Jung-Hui Yang; Cheng-Chang Lien; Meei-Ling Tsaur
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6. Mechanical sensitivity and electrophysiological properties of acutely dissociated dorsal root ganglion neurons of rats.

Authors: Viacheslav Viatchenko-Karpinski; Jianguo G Gu
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10. Enhanced excitability and suppression of A-type K(+) currents in joint sensory neurons in a murine model of antigen-induced arthritis.

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1 in total

1. Network Pharmacology Prediction: The Possible Mechanisms of Cinobufotalin against Osteosarcoma.

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1 in total

[Effect of cinobufagin on transient outward potassium current in dorsal root ganglion cells of rats with cancer-induced bone pain].

1. Melanocortin type 4 receptor-mediated inhibition of A-type K⁺ current enhances sensory neuronal excitability and mechanical pain sensitivity in rats.

2. A meta-analysis of Cinobufacini combined with transcatheterarterial chemoembolization in the treatment of advanced hepatocellular carcinoma.

Review 3. Sodium channels in normal and pathological pain.

4. The Distributions of Voltage-Gated K⁺ current Subtypes in Different Cell Sizes from Adult Mouse Dorsal Root Ganglia.

5. K⁺ Channel Modulatory Subunits KChIP and DPP Participate in Kv4-Mediated Mechanical Pain Control.

6. Mechanical sensitivity and electrophysiological properties of acutely dissociated dorsal root ganglion neurons of rats.

7. Expression of BDNF in dorsal root ganglion of rats with bone cancer pain and its effect on pain behavior.

Review 8. A-Type K_V Channels in Dorsal Root Ganglion Neurons: Diversity, Function, and Dysfunction.

9. xCT knockdown in human breast cancer cells delays onset of cancer-induced bone pain.

10. Enhanced excitability and suppression of A-type K(+) currents in joint sensory neurons in a murine model of antigen-induced arthritis.

1. Network Pharmacology Prediction: The Possible Mechanisms of Cinobufotalin against Osteosarcoma.

Review 3. Sodium channels in normal and pathological pain.

Review 8. A-Type KV Channels in Dorsal Root Ganglion Neurons: Diversity, Function, and Dysfunction.

Review 8. A-Type K_V Channels in Dorsal Root Ganglion Neurons: Diversity, Function, and Dysfunction.