| Literature DB >> 31640086 |
Zhenpeng Zhu1,2,1, Anbang He1,2,1, Tongde Lv1,2, Chunru Xu1,2, Lanruo Lin3, Jian Lin1,2.
Abstract
Prolyl 4-hydroxylase, beta polypeptide (P4HB) protein has been found to be associated with tumorigenesis in many types of tumor, However, the relationship between P4HB and clear cell renal cell carcinoma (ccRCC) has not been clarified. In this study, we focus on the correlation between P4HB expression and ccRCC. Through the Cancer Genome Atlas (TCGA) database, Gene Expression Omnibus (GEO) database, our database and immunohistochemical (IHC) staining. Compared with adjacent normal tissues, both the mRNA and protein levels of P4HB in ccRCC tissues were enhanced. The Kaplan-Meier survival analysis showed that high expression of P4HB is correlated with poor prognosis in both TCGA database and our own database. Multivariate survival analysis and Univariate analysis showed that P4HB expression and age are significantly correlative with poor prognose. All the results indicated that P4HB is correlated with poor prognosis in human clear cell renal cell carcinoma.Entities:
Keywords: GEO; P4HB; TCGA; ccRCC
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Year: 2019 PMID： 31640086 DOI： 10.3233/CBM-190450
Source DB: PubMed Journal: Cancer Biomark ISSN： 1574-0153 Impact factor: 4.388