Literature DB >> 3163907

Purification and characterization of human renal dehydropeptidase I.

S Mitsuhashi1, A Fuse, H Mikami, Y Saino, M Inoue.   

Abstract

Dehydropeptidase I from human kidney was purified over 100-fold. The purified enzyme had an isoelectric point of 4.75, apparent molecular weights of 135,000 by gel filtration and of 66,500 by sodium dodecyl sulfate-polyacrylamide gel electrophoresis, and an optimal pH of 7.4. Human renal dehydropeptidase I hydrolyzed imipenem, carpetimycins A and B, and Sch 29,482.

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Year:  1988        PMID： 3163907      PMCID： PMC172226          DOI： 10.1128/AAC.32.4.587

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN： 0066-4804            Impact factor:   5.191


  11 in total

1.  Protein measurement with the Folin phenol reagent.

Authors:  O H LOWRY; N J ROSEBROUGH; A L FARR; R J RANDALL
Journal:  J Biol Chem       Date:  1951-11       Impact factor: 5.157

2.  Purification and properties of human kidney dipeptidases.

Authors:  M Sugiura; Y Ito; K Hirano; S Sawaki
Journal:  Biochim Biophys Acta       Date:  1978-02-10

3.  A spectrophotometric assay of beta-lactamase action on penicillins.

Authors:  S G Waley
Journal:  Biochem J       Date:  1974-06       Impact factor: 3.857

4.  Cleavage of structural proteins during the assembly of the head of bacteriophage T4.

Authors:  U K Laemmli
Journal:  Nature       Date:  1970-08-15       Impact factor: 49.962

5.  Pharmacological studies on carbapenem antibiotics. II. Isolation of a PS-5-inactivating factor from the rat kidney.

Authors:  N Shibamoto; M Sakamoto; Y Fukagawa; T Ishikura
Journal:  J Antibiot (Tokyo)       Date:  1982-06       Impact factor: 2.649

6.  The purification and properties of a particulate renal dipeptidase.

Authors:  B J Campbell; Y C Lin; R V Davis; E Ballew
Journal:  Biochim Biophys Acta       Date:  1966-05-05

7.  Effect of N-formimidoyl thienamycin (MK0787) on beta-lactamases and activity against beta-lactamase-producing strains.

Authors:  M Toda; K Sato; H Nakazawa; M Inoue; S Mitsuhashi
Journal:  Antimicrob Agents Chemother       Date:  1980-11       Impact factor: 5.191

8.  Metabolism of thienamycin and related carbapenem antibiotics by the renal dipeptidase, dehydropeptidase.

Authors:  H Kropp; J G Sundelof; R Hajdu; F M Kahan
Journal:  Antimicrob Agents Chemother       Date:  1982-07       Impact factor: 5.191

9.  Comparative stability of newly introduced beta-lactam antibiotics to renal dipeptidase.

Authors:  H Mikami; M Ogashiwa; Y Saino; M Inoue; S Mitsuhashi
Journal:  Antimicrob Agents Chemother       Date:  1982-10       Impact factor: 5.191

10.  Estimation of the molecular weights of proteins by Sephadex gel-filtration.

Authors:  P Andrews
Journal:  Biochem J       Date:  1964-05       Impact factor: 3.766
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  1 in total

1.  Characterization of the glycosyl-phosphatidylinositol-anchored human renal dipeptidase reveals that it is more extensively glycosylated than the pig enzyme.

Authors:  N M Hooper; J N Keen; A J Turner
Journal:  Biochem J       Date:  1990-01-15       Impact factor: 3.857
  1 in total

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