Irene Karampela1,2, Gerasimos Socrates Christodoulatos3, Maria Dalamaga3. 1. Second Department of Critical Care, Attikon General University Hospital, Medical School, National and Kapodistrian University of Athens, 1 Rimini St, Haidari, 12462, Athens, Greece. eikaras1@gmail.com. 2. Department of Biological Chemistry, Medical School, National and Kapodistrian University of Athens, Mikras Asias 75, Goudi, 11527, Athens, Greece. eikaras1@gmail.com. 3. Department of Biological Chemistry, Medical School, National and Kapodistrian University of Athens, Mikras Asias 75, Goudi, 11527, Athens, Greece.
Abstract
PURPOSE: Sepsis has become a global health problem with rising incidence and high mortality, creating a substantial social and economic burden. Early diagnosis and treatment can improve outcome, but reliable sepsis biomarkers are lacking. This review summarizes current evidence of the pathophysiological mechanisms linking adipose tissue to sepsis and presents experimental and clinical data on adipokines and sepsis along with important insights into the obesity paradox in sepsis survival. RECENT FINDINGS: Sepsis is characterized by significant alterations in circulating cytokines and adipokines, biologically active molecules produced by the adipose tissue, being implicated in metabolic and inflammatory processes. Although data are inconclusive regarding classic adipokines such as leptin and adiponectin, recent evidence have highlighted the striking elevation of resistin and visfatin in critical illness and sepsis as well as their association with sepsis severity and outcomes. Given that inflammatory and metabolic pathways are involved in sepsis, studying adipokines presents an attractive, innovative, and promising research field that may provide more powerful diagnostic and prognostic biomarkers as well as novel therapeutic targets, empowering the therapeutic armamentarium for sepsis management in order to improve survival.
PURPOSE:Sepsis has become a global health problem with rising incidence and high mortality, creating a substantial social and economic burden. Early diagnosis and treatment can improve outcome, but reliable sepsis biomarkers are lacking. This review summarizes current evidence of the pathophysiological mechanisms linking adipose tissue to sepsis and presents experimental and clinical data on adipokines and sepsis along with important insights into the obesity paradox in sepsis survival. RECENT FINDINGS:Sepsis is characterized by significant alterations in circulating cytokines and adipokines, biologically active molecules produced by the adipose tissue, being implicated in metabolic and inflammatory processes. Although data are inconclusive regarding classic adipokines such as leptin and adiponectin, recent evidence have highlighted the striking elevation of resistin and visfatin in critical illness and sepsis as well as their association with sepsis severity and outcomes. Given that inflammatory and metabolic pathways are involved in sepsis, studying adipokines presents an attractive, innovative, and promising research field that may provide more powerful diagnostic and prognostic biomarkers as well as novel therapeutic targets, empowering the therapeutic armamentarium for sepsis management in order to improve survival.
Authors: Dominique J Pepper; Cumhur Y Demirkale; Junfeng Sun; Chanu Rhee; David Fram; Peter Eichacker; Michael Klompas; Anthony F Suffredini; Sameer S Kadri Journal: Crit Care Med Date: 2019-05 Impact factor: 7.598
Authors: Maria Dalamaga; Konstantinos Karmaniolas; Athina Nikolaidou; John Chamberland; Alex Hsi; Amalia Dionyssiou-Asteriou; Christos S Mantzoros Journal: Eur J Cancer Date: 2008-08 Impact factor: 9.162
Authors: Christian Bime; Nancy G Casanova; Sara M Camp; Radu C Oita; Juliet Ndukum; Vivian Reyes Hernon; Dong Kyu Oh; Yansong Li; Phil J Greer; David C Whitcomb; Georgios I Papachristou; Joe G N Garcia Journal: BMC Anesthesiol Date: 2022-06-15 Impact factor: 2.376