Literature DB >> 3163681

Selective enhancement of metastatic capacity in mouse bladder carcinoma cells after transfection with DNA from liver metastases of human colon carcinoma.

A Radler-Pohl1, J Pohl, V Schirrmacher.   

Abstract

To identify sequences associated with a metastatic phenotype, DNA fragments isolated from 2 separate human colon carcinoma metastases were transfected into a mouse bladder carcinoma cell line together with the neoR gene as selectable marker. It was found that bulk populations of neomycin resistant cells carrying these human sequences caused more metastases in syngeneic mice than did control cells transfected with calf thymus DNA. Cells isolated from metastases retained the highly metastatic phenotype when transferred to secondary hosts.

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Year:  1988        PMID： 3163681     DOI： 10.1002/ijc.2910410611

Source DB:  PubMed          Journal:  Int J Cancer        ISSN： 0020-7136            Impact factor:   7.396


  6 in total

1.  Induction of the metastatic phenotype by transfection of the nuclear oncogene p53: increases in cytoplasmic diacylglycerol levels and reduction in class I major histocompatibility antigen expression are not sufficient to explain the changes in metastatic capacities.

Authors:  J Pohl; V Lehmann; A Radler-Pohl; V Schirrmacher
Journal:  J Cancer Res Clin Oncol       Date:  1989       Impact factor: 4.553

Review 2.  Molecular genetics of colorectal carcinoma.

Authors:  I B Kerr
Journal:  BMJ       Date:  1989-09-09

3.  Analysis of metastatic competence of mouse bladder carcinoma cells after transfection with activated Ha-ras or N-ras oncogenes.

Authors:  J Pohl; A Radler-Pohl; L M Franks; V Schirrmacher
Journal:  J Cancer Res Clin Oncol       Date:  1988       Impact factor: 4.553

4.  Acquisition and enhanced expression of the metastatic phenotype following transfections of genomic mouse tumor DNA containing human SCLC gene sequences.

Authors:  C C Cate; D R Belloni; M Marin-Padilla
Journal:  Clin Exp Metastasis       Date:  1995-05       Impact factor: 5.150

5.  Generation of metastatic variants by transfection of a rat non-metastatic epithelial cell line with genomic DNA from rat prostatic carcinoma cells.

Authors:  Y Ke; C Beesley; P Smith; R Barraclough; P Rudland; C S Foster
Journal:  Br J Cancer       Date:  1998       Impact factor: 7.640

6.  Identification of genes controlling metastatic behaviour.

Authors:  I R Hart; D Easty
Journal:  Br J Cancer       Date:  1991-01       Impact factor: 7.640
  6 in total

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