Literature DB >> 31634759

TRPing the homeostatic alarm - Melanoma cells are selectively vulnerable to TRPML1 deletion.

Jewon Jung1, Kartik Venkatachalam2.   

Abstract

To thrive in otherwise inhospitable conditions, cancer cells utilize endolysosomes to impose homeostatic control over cellular metabolism and growth. In a recent study, Kasitinon et al. demonstrate a requirement for the endolysosomal channel, TRPML1, in proliferation and survival of melanoma cells. This study adds to a growing list of cancers that exhibit selective vulnerability to the loss of TRPML1.
Copyright © 2019 Elsevier Ltd. All rights reserved.

Entities:  

Year:  2019        PMID： 31634759      PMCID： PMC7271819          DOI： 10.1016/j.ceca.2019.102082

Source DB:  PubMed          Journal:  Cell Calcium        ISSN： 0143-4160            Impact factor:   6.817


  10 in total

1.  Coexpression of NRASQ61R and BRAFV600E in human melanoma cells activates senescence and increases susceptibility to cell-mediated cytotoxicity.

Authors:  Carlotta Petti; Alessandra Molla; Claudia Vegetti; Soldano Ferrone; Andrea Anichini; Marialuisa Sensi
Journal:  Cancer Res       Date:  2006-07-01       Impact factor: 12.701

2.  RAB7 controls melanoma progression by exploiting a lineage-specific wiring of the endolysosomal pathway.

Authors:  Direna Alonso-Curbelo; Erica Riveiro-Falkenbach; Eva Pérez-Guijarro; Metehan Cifdaloz; Panagiotis Karras; Lisa Osterloh; Diego Megías; Estela Cañón; Tonantzin G Calvo; David Olmeda; Gonzalo Gómez-López; Osvaldo Graña; Víctor Javier Sánchez-Arévalo Lobo; David G Pisano; Hao-Wei Wang; Pablo Ortiz-Romero; Damià Tormo; Keith Hoek; José L Rodríguez-Peralto; Johanna A Joyce; María S Soengas
Journal:  Cancer Cell       Date:  2014-06-26       Impact factor: 31.743

3.  HRAS-driven cancer cells are vulnerable to TRPML1 inhibition.

Authors:  Jewon Jung; Kwang-Jin Cho; Ali K Naji; Kristen N Clemons; Ching On Wong; Mariana Villanueva; Steven Gregory; Nicholas E Karagas; Lingxiao Tan; Hong Liang; Morgan A Rousseau; Kelly M Tomasevich; Andrew G Sikora; Ilya Levental; Dharini van der Hoeven; Yong Zhou; John F Hancock; Kartik Venkatachalam
Journal:  EMBO Rep       Date:  2019-02-20       Impact factor: 8.807

4.  MITF drives endolysosomal biogenesis and potentiates Wnt signaling in melanoma cells.

Authors:  Diego Ploper; Vincent F Taelman; Lidia Robert; Brian S Perez; Björn Titz; Hsiao-Wang Chen; Thomas G Graeber; Erika von Euw; Antoni Ribas; Edward M De Robertis
Journal:  Proc Natl Acad Sci U S A       Date:  2015-01-20       Impact factor: 11.205

5.  Drosophila TRPML is required for TORC1 activation.

Authors:  Ching-On Wong; Ruoxia Li; Craig Montell; Kartik Venkatachalam
Journal:  Curr Biol       Date:  2012-08-02       Impact factor: 10.834

6.  A gene network regulating lysosomal biogenesis and function.

Authors:  Marco Sardiello; Michela Palmieri; Alberto di Ronza; Diego Luis Medina; Marta Valenza; Vincenzo Alessandro Gennarino; Chiara Di Malta; Francesca Donaudy; Valerio Embrione; Roman S Polishchuk; Sandro Banfi; Giancarlo Parenti; Elena Cattaneo; Andrea Ballabio
Journal:  Science       Date:  2009-06-25       Impact factor: 47.728

7.  A lysosome-to-nucleus signalling mechanism senses and regulates the lysosome via mTOR and TFEB.

Authors:  Carmine Settembre; Roberto Zoncu; Diego L Medina; Francesco Vetrini; Serkan Erdin; SerpilUckac Erdin; Tuong Huynh; Mathieu Ferron; Gerard Karsenty; Michel C Vellard; Valeria Facchinetti; David M Sabatini; Andrea Ballabio
Journal:  EMBO J       Date:  2012-02-17       Impact factor: 11.598

8.  The lysosomal TRPML1 channel regulates triple negative breast cancer development by promoting mTORC1 and purinergic signaling pathways.

Authors:  Mengnan Xu; Shekoufeh Almasi; Yiming Yang; Chi Yan; Andra Mihaela Sterea; Alia Kazim Rizvi Syeda; Bing Shen; Clements Richard Derek; Peng Huang; Shashi Gujar; Jun Wang; Wei-Xing Zong; Mohamed Trebak; Yassine El Hiani; Xian-Ping Dong
Journal:  Cell Calcium       Date:  2019-03-02       Impact factor: 4.690

9.  TRPML1 Promotes Protein Homeostasis in Melanoma Cells by Negatively Regulating MAPK and mTORC1 Signaling.

Authors:  Stacy Y Kasitinon; Ugur Eskiocak; Misty Martin; Divya Bezwada; Vishal Khivansara; Alpaslan Tasdogan; Zhiyu Zhao; Thomas Mathews; Arin B Aurora; Sean J Morrison
Journal:  Cell Rep       Date:  2019-08-27       Impact factor: 9.423

Review 10.  The role of the endosomal sorting complexes required for transport (ESCRT) in tumorigenesis.

Authors:  Claudia Mattissek; David Teis
Journal:  Mol Membr Biol       Date:  2014-03-18       Impact factor: 2.857
  10 in total
  3 in total

1.  Lysosomal inhibition sensitizes TMEM16A-expressing cancer cells to chemotherapy.

Authors:  Avani Vyas; Roberto Gomez-Casal; Silvia Cruz-Rangel; Hugo Villanueva; Andrew G Sikora; Pavithra Rajagopalan; Devraj Basu; Jonathan Pacheco; Gerald R V Hammond; Kirill Kiselyov; Umamaheswar Duvvuri
Journal:  Proc Natl Acad Sci U S A       Date:  2022-03-14       Impact factor: 12.779

Review 2.  Targeting Lysosomes in Cancer as Promising Strategy to Overcome Chemoresistance-A Mini Review.

Authors:  Franz Geisslinger; Martin Müller; Angelika M Vollmar; Karin Bartel
Journal:  Front Oncol       Date:  2020-07-09       Impact factor: 6.244

3.  Emerging Role of Mucolipins TRPML Channels in Cancer.

Authors:  Giorgio Santoni; Matteo Santoni; Federica Maggi; Oliviero Marinelli; Maria Beatrice Morelli
Journal:  Front Oncol       Date:  2020-04-28       Impact factor: 6.244
  3 in total

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