Literature DB >> 31634194

Impact of immediate initiation of antiretroviral therapy on HIV patient satisfaction.

Osondu Ogbuoji1, Pascal Geldsetzer1, Cebele Wong2, Shaukat Khan2, Emma Mafara2, Charlotte Lejeune2, Fiona Walsh3, Velephi Okello4, Till Bärnighausen1,5,6.   

Abstract

OBJECTIVES: Immediate ART (or early access to ART for all, EAAA) is becoming a national policy in many countries in sub-Saharan Africa. It is plausible that the switch from delayed to immediate ART could either increase or decrease patient satisfaction with treatment. A decrease in patient satisfaction would likely have detrimental consequences for long-term retention and adherence, in addition to the value lost because of the worsening patient experience itself. We conducted a pragmatic stepped-wedge cluster-randomized controlled trial (SW-cRCT) to determine the causal impact of immediate treatment for HIV on patient satisfaction.
DESIGN: This seven-step SW-cRCT took place in 14 public-sector health facilities in Eswatini's Hhohho region, from September 2014 to August 2017.
METHODS: During each step of the trial, we randomly selected days for data collection at each study facility. During these days, a random sample of HIV patients were selected for outcome assessment. In total, 2629 patients provided data on their overall patient satisfaction and satisfaction with the following four domains of the patient experience using a five-point Likert scale: wait time, consultation time, involvement in treatment decisions, and respectful treatment. Higher values on the Likert scale indicated lower patient satisfaction. We analyzed the data using a multilevel ordered logistic regression model with individuals at the first level and health facilities at the second (cluster) level.
RESULTS: The proportional odds ratio (OR) comparing EAAA to control was 0.91 (95% CI 0.66-1.25) for overall patient satisfaction. For the specific domains of the patient experience, the ORs describing the impact of EAAA on satisfaction were 1.04 (95% CI 0.61-1.78) for wait time, 0.90 (95% CI 0.62-1.31) for involvement in treatment decisions, 0.86 (95% CI 0.61-1.20) for consultation time, and 1.35 (95% CI 0.93-1.96) for respectful treatment. These results were robust across a wide range of sensitivity analyses. Over time - and independent of EAAA - we observed a worsening trend for both overall patient satisfaction and satisfaction in the four domains of the patient experience we measured.
CONCLUSION: Our findings support the policy change from delayed to immediate ART in sub-Saharan Africa. Immediate (versus delayed) ART in public-sector health facilities in Eswatini had no effect on either overall patient satisfaction or satisfaction with four specific domains of the patient experience. At the same time, we observed a strong secular trend of decreasing patient satisfaction in both the intervention and the control arm of the trial. Further implementation research should identify approaches to ensure high patient satisfaction as ART programs grow and mature.

Entities:  

Mesh:

Substances:

Year:  2020        PMID: 31634194     DOI: 10.1097/QAD.0000000000002392

Source DB:  PubMed          Journal:  AIDS        ISSN: 0269-9370            Impact factor:   4.177


  3 in total

1.  A stepped-wedge randomized trial and qualitative survey of HIV pre-exposure prophylaxis uptake in the Eswatini population.

Authors:  Pascal Geldsetzer; Kate Bärnighausen; Anita Hettema; Shannon A McMahon; Shona Dalal; Rachel P Chase; Catherine E Oldenburg; Stefan Kohler; Simiao Chen; Phiwayinkhosi Dlamini; Mxolisi Mavuso; Allison B Hughey; Sindy Matse; Till Bärnighausen
Journal:  Sci Transl Med       Date:  2020-09-23       Impact factor: 17.956

2.  Early access to antiretroviral therapy versus standard of care among HIV-positive participants in Eswatini in the public health sector: the MaxART stepped-wedge randomized controlled trial.

Authors:  Shaukat Khan; Donna Spiegelman; Fiona Walsh; Sikhatele Mazibuko; Munyaradzi Pasipamire; Boyang Chai; Ria Reis; Khudzie Mlambo; Wim Delva; Gavin Khumalo; Mandisa Zwane; Yvette Fleming; Emma Mafara; Anita Hettema; Charlotte Lejeune; Ariel Chao; Till Bärnighausen; Velephi Okello
Journal:  J Int AIDS Soc       Date:  2020-09       Impact factor: 6.707

3.  The Impact of Immediate Initiation of Antiretroviral Therapy on Patients' Healthcare Expenditures: A Stepped-Wedge Randomized Trial in Eswatini.

Authors:  Janina I Steinert; Shaukat Khan; Emma Mafara; Cebele Wong; Khudzie Mlambo; Anita Hettema; Fiona J Walsh; Charlotte Lejeune; Sikhathele Mazibuko; Velephi Okello; Osondu Ogbuoji; Jan-Walter De Neve; Sebastian Vollmer; Till Bärnighausen; Pascal Geldsetzer
Journal:  AIDS Behav       Date:  2021-04-08
  3 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.