| Literature DB >> 31633842 |
Marie-Ange Dagnelie1, Stéphane Corvec2, Amir Khammari1, Brigitte Dréno1.
Abstract
Bacterial extracellular vesicles (EVs) are bilayered lipid membrane structures, bearing integral proteins and able to carry diverse cargo outside the cell to distant sites. In microorganisms, EVs carry several types of molecules: proteins, glycoproteins, mRNAs and small RNA species, as mammalian EVs do, but also carbohydrates. Studying EVs opens a whole new world of possibilities to better understand the interplay between host and bacteria crosstalks, although there are still many questions to be answered in the field, especially when it comes to microbiota-derived EVs. In this review, we propose to summarize and analyse the current literature about bacterial EVs and possible clinical applications, through answering three main questions: (a) What are bacterial EVs? (b) What are EV impacts on skin inflammatory disease physiopathology? (iii) What are the possible and expected clinical applications of EVs to treat inflammatory skin diseases?Entities:
Keywords: cell-to-cell communication; exosomes; extracellular vesicles; microbiota; probiotics; skin microbiota
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Year: 2019 PMID： 31633842 DOI： 10.1111/exd.14050
Source DB: PubMed Journal: Exp Dermatol ISSN： 0906-6705 Impact factor: 3.960