Sílvia Xargay-Torrent 1 , Estefanía Dorado-Ceballos 2 , Anna Benavides-Boixader 1 , Esther Lizárraga-Mollinedo 1 , Berta Mas-Parés 3 , Mercè Montesinos-Costa 4 , Francis De Zegher 5 , Lourdes Ibáñez 6,7 , Judit Bassols 3 , Abel López-Bermejo 1,2 Show Affiliations »
Abstract
OBJECTIVE: To study the association between IGF-I and blood pressure in children, in particular, the potential interaction with the serum calcium-phosphorus product (Ca*P) in this association. METHODS: In a longitudinal study, 521 children (age 8.8 ± 0.1) from North-Eastern Spain were studied, of whom 158 were followed-up after 5 years. IGF-I, IGFBP-3, serum calcium and phosphorus were measured at baseline. Anthropometric [body-mass index (BMI) and waist] and cardio-metabolic [systolic (SBP) and diastolic blood pressure, pulse pressure, insulin, homeostatic model assessment of insulin resistance (HOMA-IR), HDL cholesterol and triglycerides] variables were assessed at baseline and at the end of follow-up. Statistical analysis included Pearson correlations followed by multivariable linear regression analyses. RESULTS: Baseline IGF-I and IGF-I/IGFBP-3 molar ratio positively correlated with baseline and follow-up BMI, waist, SBP, pulse pressure, insulin, HOMA-IR and triglycerides (r from 0.138 to 0.603; all p<0.05). The associations with SBP were stronger with increasing Ca*P (r from 0.261 to 0.625 for IGF-I; and r from 0.174 to 0.583 for IGF-I/IGFBP-3). After adjusting for confounding variables, baseline IGF-I and IGF-I/IGFBP-3 remained independently associated with both baseline and follow-up SBP in children in the highest Ca*P tertile (β from 0.245 to 0.381; p<0.01; model R2 from 0.246 to 0.566). CONCLUSIONS: Our results suggest that IGF-I in childhood is an independent predictor of SBP in apparently healthy children, especially in those with high Ca*P levels. © Endocrine Society 2019. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.
OBJECTIVE: To study the association between IGF-I and blood pressure in children , in particular, the potential interaction with the serum calcium-phosphorus product (Ca*P) in this association. METHODS: In a longitudinal study, 521 children (age 8.8 ± 0.1) from North-Eastern Spain were studied, of whom 158 were followed-up after 5 years. IGF-I , IGFBP-3 , serum calcium and phosphorus were measured at baseline. Anthropometric [body-mass index (BMI) and waist] and cardio-metabolic [systolic (SBP ) and diastolic blood pressure, pulse pressure, insulin , homeostatic model assessment of insulin resistance (HOMA-IR), HDL cholesterol and triglycerides ] variables were assessed at baseline and at the end of follow-up. Statistical analysis included Pearson correlations followed by multivariable linear regression analyses. RESULTS: Baseline IGF-I and IGF-I /IGFBP-3 molar ratio positively correlated with baseline and follow-up BMI, waist, SBP , pulse pressure, insulin , HOMA-IR and triglycerides (r from 0.138 to 0.603; all p<0.05). The associations with SBP were stronger with increasing Ca*P (r from 0.261 to 0.625 for IGF-I ; and r from 0.174 to 0.583 for IGF-I /IGFBP-3 ). After adjusting for confounding variables, baseline IGF-I and IGF-I /IGFBP-3 remained independently associated with both baseline and follow-up SBP in children in the highest Ca*P tertile (β from 0.245 to 0.381; p<0.01; model R2 from 0.246 to 0.566). CONCLUSIONS: Our results suggest that IGF-I in childhood is an independent predictor of SBP in apparently healthy children , especially in those with high Ca*P levels. © Endocrine Society 2019. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.
Entities: Chemical
Gene
Species
Keywords:
IGF-I; IGFBP-3; calcium-phosphorus product; hypertension
Year: 2019
PMID： 31633765 DOI： 10.1210/clinem/dgz101
Source DB: PubMed Journal: J Clin Endocrinol Metab ISSN： 0021-972X Impact factor: 5.958