Chloe W Eng1,2, Paola Gilsanz1, Mary E Lacy1,2, Michal Schnaider Beeri3,4, Rachel A Whitmer1,2,5. 1. Kaiser Permanente Northern California Division of Research, Oakland. 2. Department of Epidemiology and Biostatistics, University of California, San Francisco, San Francisco. 3. Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY. 4. The Joseph Sagol Neuroscience Center, Sheba Medical Center, Ramat Gan, Israel. 5. Department of Public Health Sciences, University of California, Davis, Davis, CA.
Abstract
OBJECTIVE: Life expectancy for individuals with type 1 diabetes mellitus (T1DM) has increased recently; however, it is unknown how diabetes care attitudes affect late-life brain health. RESEARCH DESIGN AND METHODS: The Study of Longevity in Diabetes (SOLID) consists of 734 older adults with T1DM, reporting diabetes locus of control (dLOC), age of diabetes diagnosis and other demographics, history of hypoglycemic episodes, and depressive symptoms. Global and domain-specific (language, executive function, episodic memory, simple attention) cognitive functioning was assessed at in-person interviews. Cross-sectional associations between dLOC and cognition were estimated using covariate-adjusted linear regression models in pooled and sex-stratified models. RESULTS: In pooled analyses, a 1-point increase in dLOC (more internal) was positively associated with global cognition [β=0.05, 95% confidence interval (CI): 0.02, 0.07], language (β=0.04, 95% CI: 0.01, 0.07), and executive function (β=0.04, 95% CI: 0.01, 0.07), but not episodic memory or simple attention. However, in sex-stratified analyses, this effect was seen only in males and not females. CONCLUSIONS: In elderly individuals with T1DM, we found associations between dLOC and cognition overall and in men but not women. Underlying sex differences should be considered in future research or interventions on psychosocial characteristics for cognition.
OBJECTIVE: Life expectancy for individuals with type 1 diabetes mellitus (T1DM) has increased recently; however, it is unknown how diabetes care attitudes affect late-life brain health. RESEARCH DESIGN AND METHODS: The Study of Longevity in Diabetes (SOLID) consists of 734 older adults with T1DM, reporting diabetes locus of control (dLOC), age of diabetes diagnosis and other demographics, history of hypoglycemic episodes, and depressive symptoms. Global and domain-specific (language, executive function, episodic memory, simple attention) cognitive functioning was assessed at in-person interviews. Cross-sectional associations between dLOC and cognition were estimated using covariate-adjusted linear regression models in pooled and sex-stratified models. RESULTS: In pooled analyses, a 1-point increase in dLOC (more internal) was positively associated with global cognition [β=0.05, 95% confidence interval (CI): 0.02, 0.07], language (β=0.04, 95% CI: 0.01, 0.07), and executive function (β=0.04, 95% CI: 0.01, 0.07), but not episodic memory or simple attention. However, in sex-stratified analyses, this effect was seen only in males and not females. CONCLUSIONS: In elderly individuals with T1DM, we found associations between dLOC and cognition overall and in men but not women. Underlying sex differences should be considered in future research or interventions on psychosocial characteristics for cognition.
Authors: Regina C Sims; Keith E Whitfield; Brian J Ayotte; Alyssa A Gamaldo; Christopher L Edwards; Jason C Allaire Journal: Exp Aging Res Date: 2011-03 Impact factor: 1.645
Authors: Mohammad Ali Morowatisharifabad; Seid Saeed Mazloomy Mahmoodabad; Mohammad Hossein Baghianimoghadam; Nooshin Rouhani Tonekaboni Journal: Int J Diabetes Dev Ctries Date: 2010-01