Literature DB >> 31632752

Breathing lung transplantation with the Organ Care System (OCS) Lung: lessons learned and future implications.

William Lightle1, Daoud Daoud1, Gabriel Loor1.   

Abstract

Ex vivo lung perfusion (EVLP) represents a potentially important advancement in the preservation of donor lungs prior to transplantation. Portable EVLP or "Breathing Lung Transplantation" with the Organ Care System (OCS) Lung combines the fundamental components of EVLP with portability, thus reducing the total ischemic burden. The Food and Drug Administration (FDA) approved OCS for perfusion of standard donor lungs prior to transplant in 2018. The current review discusses the available literature on the clinical outcomes of OCS Lung as well as translational data. 2019 Journal of Thoracic Disease. All rights reserved.

Entities:  

Keywords:  Ex vivo lung perfusion (EVLP); Organ Care System (OCS); donor lung; lung transplantation

Year:  2019        PMID： 31632752      PMCID： PMC6783715          DOI： 10.21037/jtd.2019.03.32

Source DB:  PubMed          Journal:  J Thorac Dis        ISSN： 2072-1439            Impact factor:   2.895


  22 in total

1.  Normothermic ex-vivo preservation with the portable Organ Care System Lung device for bilateral lung transplantation (INSPIRE): a randomised, open-label, non-inferiority, phase 3 study.

Authors:  Gregor Warnecke; Dirk Van Raemdonck; Michael A Smith; Gilbert Massard; Jasleen Kukreja; Federico Rea; Gabriel Loor; Fabio De Robertis; Jayan Nagendran; Kumud K Dhital; Francisco Javier Moradiellos Díez; Christoph Knosalla; Christian A Bermudez; Steven Tsui; Kenneth McCurry; I-Wen Wang; Tobias Deuse; Guy Lesèche; Pascal Thomas; Igor Tudorache; Christian Kühn; Murat Avsar; Bettina Wiegmann; Wiebke Sommer; Arne Neyrinck; Marco Schiavon; Fiorella Calabrese; Nichola Santelmo; Anne Olland; Pierre-Emanuel Falcoz; Andre R Simon; Andres Varela; Joren C Madsen; Marshall Hertz; Axel Haverich; Abbas Ardehali
Journal:  Lancet Respir Med       Date:  2018-04-09       Impact factor: 30.700

2.  Normothermic ex vivo lung perfusion in clinical lung transplantation.

Authors:  Marcelo Cypel; Jonathan C Yeung; Mingyao Liu; Masaki Anraku; Fengshi Chen; Wojtek Karolak; Masaaki Sato; Jane Laratta; Sassan Azad; Mindy Madonik; Chung-Wai Chow; Cecilia Chaparro; Michael Hutcheon; Lianne G Singer; Arthur S Slutsky; Kazuhiro Yasufuku; Marc de Perrot; Andrew F Pierre; Thomas K Waddell; Shaf Keshavjee
Journal:  N Engl J Med       Date:  2011-04-14       Impact factor: 91.245

3.  Utilization of the Organ Care System Lung for the assessment of lungs from a donor after cardiac death (DCD) before bilateral transplantation.

Authors:  P N Mohite; A Sabashnikov; D García Sáez; B Pates; M Zeriouh; F De Robertis; A R Simon
Journal:  Perfusion       Date:  2014-10-20       Impact factor: 1.972

Review 4.  Report of the International Society for Heart and Lung Transplantation Working Group on Primary Lung Graft Dysfunction, part II: Epidemiology, risk factors, and outcomes-A 2016 Consensus Group statement of the International Society for Heart and Lung Transplantation.

Authors:  Joshua M Diamond; Selim Arcasoy; Cassie C Kennedy; Michael Eberlein; Jonathan P Singer; Glenda M Patterson; Jeffrey D Edelman; Gundeep Dhillon; Tahuanty Pena; Steven M Kawut; James C Lee; Reda Girgis; John Dark; Gabriel Thabut
Journal:  J Heart Lung Transplant       Date:  2017-07-26       Impact factor: 10.247

5.  The International Thoracic Organ Transplant Registry of the International Society for Heart and Lung Transplantation: Thirty-fifth adult lung and heart-lung transplant report-2018; Focus theme: Multiorgan Transplantation.

Authors:  Daniel C Chambers; Wida S Cherikh; Samuel B Goldfarb; Don Hayes; Anna Y Kucheryavaya; Alice E Toll; Kiran K Khush; Bronwyn J Levvey; Bruno Meiser; Joseph W Rossano; Josef Stehlik
Journal:  J Heart Lung Transplant       Date:  2018-08-11       Impact factor: 10.247

6.  Lung transplant after prolonged ex vivo lung perfusion: predictors of allograft function in swine.

Authors:  John R Spratt; Lars M Mattison; Paul A Iaizzo; Carolyn Meyer; Roland Z Brown; Tinen Iles; Angela Panoskaltsis-Mortari; Gabriel Loor
Journal:  Transpl Int       Date:  2018-07-31       Impact factor: 3.782

7.  Prolonged EVLP Using OCS Lung: Cellular and Acellular Perfusates.

Authors:  Gabriel Loor; Brian T Howard; John R Spratt; Lars M Mattison; Angela Panoskaltsis-Mortari; Roland Z Brown; Tinen L Iles; Carolyn M Meyer; Haylie R Helms; Andrew Price; Paul A Iaizzo
Journal:  Transplantation       Date:  2017-10       Impact factor: 4.939

8.  Extended criteria donor lung reconditioning with the organ care system lung: a single institution experience.

Authors:  Marco Schiavon; Giulio Faggi; Alessandro Rebusso; Francesca Lunardi; Giovanni Comacchio; Guido Di Gregorio; Paolo Feltracco; Dario Gregori; Fiorella Calabrese; Giuseppe Marulli; Emanuele Cozzi; Rea Federico
Journal:  Transpl Int       Date:  2018-11-13       Impact factor: 3.782

9.  Deaths: Leading Causes for 2016.

Authors:  Melonie Heron
Journal:  Natl Vital Stat Rep       Date:  2018-07

10.  Prediction of transplant outcome after 24-hour ex vivo lung perfusion using the Organ Care System in a porcine lung transplantation model.

Authors:  Wiebke Sommer; Jawad Salman; Murat Avsar; Klaus Hoeffler; Katharina Jansson; Thierry N Siemeni; Ann-Kathrin Knoefel; Linda Ahrens; Reza Poyanmehr; Igor Tudorache; Peter Braubach; Danny Jonigk; Axel Haverich; Gregor Warnecke
Journal:  Am J Transplant       Date:  2018-09-12       Impact factor: 8.086
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  1 in total

Review 1.  Ex Vivo Lung Perfusion: Current Achievements and Future Directions.

Authors:  Nikhil K Prasad; Chetan Pasrija; Tara Talaie; Alexander S Krupnick; Yunge Zhao; Christine L Lau
Journal:  Transplantation       Date:  2021-05-01       Impact factor: 4.939
  1 in total

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