Cem Mirili1, Semra Paydas2, Tuba Korkmaz Kapukaya3, Ali Yılmaz1. 1. Department Of Medical Oncology, Faculty of Medicine, Ataturk University, Yakutiye, Erzurum, Turkey. 2. Department Of Medical Oncology, Faculty of Medicine, Çukurova University, Sarıcam, Adana, Turkey. 3. Department Of Internal Medicine, Faculty of Medicine, Çukurova University, Sarıcam, Adana, Turkey.
Abstract
Aim: To evaluate the prognostic significance of neutrophil lymphocyte ratio, prognostic nutritional index, systemic immune-inflammation index (SII) and B2M in Hodgkin Lymphoma (HL). Materials & methods: Neutrophil-lymphocyte ratio, prognostic nutritional index, SII and B2M were analyzed to assess their prognostic value via the Kaplan-Meier method and Cox regression analysis in 122 HL patients, retrospectively. Results: SII was found to have the highest area under curve and the most sensitive and specific among all markers. In univariate analyses, all four parameters were prognostic for overall survival and progression-free survival, in multivariate analyzes only SII was found to be independent factors for both of them. Conclusion: SII can be suggested as a novel independent and better prognostic factor for predicting overall survival and progression-free survival in HL.
Aim: To evaluate the prognostic significance of neutrophil lymphocyte ratio, prognostic nutritional index, systemic immune-inflammation index (SII) and B2M in Hodgkin Lymphoma (HL). Materials & methods: Neutrophil-lymphocyte ratio, prognostic nutritional index, SII and B2M were analyzed to assess their prognostic value via the Kaplan-Meier method and Cox regression analysis in 122 HLpatients, retrospectively. Results: SII was found to have the highest area under curve and the most sensitive and specific among all markers. In univariate analyses, all four parameters were prognostic for overall survival and progression-free survival, in multivariate analyzes only SII was found to be independent factors for both of them. Conclusion: SII can be suggested as a novel independent and better prognostic factor for predicting overall survival and progression-free survival in HL.
Authors: Katarina Kalavska; Zuzana Sestakova; Andrea Mlcakova; Paulina Gronesova; Viera Miskovska; Katarina Rejlekova; Daniela Svetlovska; Zuzana Sycova-Mila; Jana Obertova; Patrik Palacka; Jozef Mardiak; Miroslav Chovanec; Michal Chovanec; Michal Mego Journal: Life (Basel) Date: 2022-05-02