Alexandra Legge1, Susan Kirkland1, Kenneth Rockwood1, Pantelis Andreou1, Sang-Cheol Bae2, Caroline Gordon3, Juanita Romero-Diaz4, Jorge Sanchez-Guerrero4, Daniel J Wallace5, Sasha Bernatsky6, Ann E Clarke7, Joan T Merrill8, Ellen M Ginzler9, Paul R Fortin10, Dafna D Gladman11, Murray B Urowitz11, Ian N Bruce12, David A Isenberg13, Anisur Rahman13, Graciela S Alarcón14, Michelle Petri15, Munther A Khamashta16, M A Dooley17, Rosalind Ramsey-Goldman18, Susan Manzi19, Asad A Zoma20, Cynthia Aranow21, Meggan Mackay21, Guillermo Ruiz-Irastorza22, S Sam Lim23, Murat Inanc24, Ronald F van Vollenhoven25, Andreas Jonsen26, Ola Nived26, Manuel Ramos-Casals27, Diane L Kamen28, Kenneth C Kalunian29, Soren Jacobsen30, Christine A Peschken31, Anca Askanase32, John G Hanly33. 1. Dalhousie University, Halifax, Nova Scotia, Canada. 2. Hanyang University Hospital for Rheumatic Diseases, Seoul, Korea. 3. University of Birmingham College of Medical and Dental Sciences, Birmingham, UK. 4. Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubiran, Mexico City, Mexico. 5. Cedars-Sinai Medical Center and David Geffen School of Medicine at University of California, Los Angeles. 6. McGill University, Montreal, Quebec, Canada. 7. University of Calgary Cumming School of Medicine, Calgary, Alberta, Canada. 8. Oklahoma Medical Research Foundation, Oklahoma City. 9. SUNY Downstate Medical Center, New York, New York. 10. CHU de Quebec-Université Laval, Quebec City, Quebec, Canada. 11. Toronto Western Hospital and University of Toronto, Toronto, Ontario, Canada. 12. Arthritis Research UK Epidemiology Unit, University of Manchester, NIHR Manchester Musculoskeletal Biomedical Research Centre, and Manchester University NHS Foundation Trust, Manchester, UK. 13. University College London, London, UK. 14. University of Alabama at Birmingham. 15. Johns Hopkins University School of Medicine, Baltimore, Maryland. 16. St. Thomas Hospital and King's College London GKT School of Medical Education, London, UK. 17. University of North Carolina at Chapel Hill. 18. Northwestern University and Feinberg School of Medicine, Chicago, Illinois. 19. Lupus Center of Excellence, Allegheny Health Network, Pittsburgh, Pennsylvania. 20. Hairmyres Hospital, East Kilbride, UK. 21. Feinstein Institute for Medical Research, Manhasset, New York. 22. Hospital Universitario Cruces, University of the Basque Country, Barakaldo, Spain. 23. Emory University School of Medicine, Atlanta, Georgia. 24. Istanbul University, Istanbul, Turkey. 25. Karolinska Institute, Stockholm, Sweden. 26. Lund University, Lund, Sweden. 27. Institut d'Investigacions Biomèdiques August Pi i Sunyer and Hospital Clínic, Barcelona, Barcelona, Spain. 28. Medical University of South Carolina, Charleston. 29. University of California, San Diego School of Medicine. 30. Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark. 31. University of Manitoba, Winnipeg, Manitoba, Canada. 32. Hospital for Joint Diseases, New York University New York, New York. 33. Queen Elizabeth II Health Sciences Center and Dalhousie University, Halifax, Nova Scotia, Canada.
Abstract
OBJECTIVE: The Systemic Lupus International Collaborating Clinics (SLICC) frailty index (FI) has been shown to predict mortality, but its association with other important outcomes is unknown. We examined the association of baseline SLICC FI values with damage accrual in the SLICC inception cohort. METHODS: The baseline visit was defined as the first visit at which both organ damage (SLICC/American College of Rheumatology Damage Index [SDI]) and health-related quality of life (Short Form 36) were assessed. Baseline SLICC FI scores were calculated. Damage accrual was measured by the increase in SDI between the baseline assessment and the last study visit. Multivariable negative binomial regression was used to estimate the association between baseline SLICC FI values and the rate of increase in the SDI during follow-up, adjusting for relevant demographic and clinical characteristics. RESULTS: The 1,549 systemic lupus erythematosus (SLE) patients eligible for this analysis were mostly female (88.7%) with a mean ± SD age of 35.7 ± 13.3 years and a median disease duration of 1.2 years (interquartile range 0.9-1.5 years) at baseline. The mean ± SD baseline SLICC FI was 0.17 ± 0.08. Over a mean ± SD follow-up of 7.2 ± 3.7 years, 653 patients (42.2%) had an increase in SDI. Higher baseline SLICC FI values (per 0.05 increase) were associated with higher rates of increase in the SDI during follow-up (incidence rate ratio [IRR] 1.19 [95% confidence interval 1.13-1.25]), after adjusting for age, sex, ethnicity/region, education, baseline SLE Disease Activity Index 2000, baseline SDI, and baseline use of glucocorticoids, antimalarials, and immunosuppressive agents. CONCLUSION: Our findings indicate that the SLICC FI predicts damage accrual in incident SLE, which further supports the SLICC FI as a valid health measure in SLE.
OBJECTIVE: The Systemic Lupus International Collaborating Clinics (SLICC) frailty index (FI) has been shown to predict mortality, but its association with other important outcomes is unknown. We examined the association of baseline SLICC FI values with damage accrual in the SLICC inception cohort. METHODS: The baseline visit was defined as the first visit at which both organ damage (SLICC/American College of Rheumatology Damage Index [SDI]) and health-related quality of life (Short Form 36) were assessed. Baseline SLICC FI scores were calculated. Damage accrual was measured by the increase in SDI between the baseline assessment and the last study visit. Multivariable negative binomial regression was used to estimate the association between baseline SLICC FI values and the rate of increase in the SDI during follow-up, adjusting for relevant demographic and clinical characteristics. RESULTS: The 1,549 systemic lupus erythematosus (SLE) patients eligible for this analysis were mostly female (88.7%) with a mean ± SD age of 35.7 ± 13.3 years and a median disease duration of 1.2 years (interquartile range 0.9-1.5 years) at baseline. The mean ± SD baseline SLICC FI was 0.17 ± 0.08. Over a mean ± SD follow-up of 7.2 ± 3.7 years, 653 patients (42.2%) had an increase in SDI. Higher baseline SLICC FI values (per 0.05 increase) were associated with higher rates of increase in the SDI during follow-up (incidence rate ratio [IRR] 1.19 [95% confidence interval 1.13-1.25]), after adjusting for age, sex, ethnicity/region, education, baseline SLE Disease Activity Index 2000, baseline SDI, and baseline use of glucocorticoids, antimalarials, and immunosuppressive agents. CONCLUSION: Our findings indicate that the SLICC FI predicts damage accrual in incident SLE, which further supports the SLICC FI as a valid health measure in SLE.
Authors: Kirsten K Ness; Gregory T Armstrong; Mondira Kundu; Carmen L Wilson; Tamara Tchkonia; James L Kirkland Journal: Cancer Date: 2014-12-19 Impact factor: 6.860
Authors: Alexandra Legge; Susan Kirkland; Kenneth Rockwood; Pantelis Andreou; Sang-Cheol Bae; Caroline Gordon; Juanita Romero-Diaz; Jorge Sanchez-Guerrero; Daniel J Wallace; Sasha Bernatsky; Ann E Clarke; Joan T Merrill; Ellen M Ginzler; Paul Fortin; Dafna D Gladman; Murray B Urowitz; Ian N Bruce; David A Isenberg; Anisur Rahman; Graciela S Alarcón; Michelle Petri; Munther A Khamashta; M A Dooley; Rosalind Ramsey-Goldman; Susan Manzi; Kristjan Steinsson; Asad A Zoma; Cynthia Aranow; Meggan Mackay; Guillermo Ruiz-Irastorza; S Sam Lim; Murat Inanc; Ronald F van Vollenhoven; Andreas Jonsen; Ola Nived; Manuel Ramos-Casals; Diane L Kamen; Kenneth C Kalunian; Soren Jacobsen; Christine A Peschken; Anca Askanase; John G Hanly Journal: Arthritis Rheumatol Date: 2019-05-29 Impact factor: 10.995
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Authors: Manuel Francisco Ugarte-Gil; Anselm Mak; Joanna Leong; Bhushan Dharmadhikari; Nien Yee Kow; Cristina Reátegui-Sokolova; Claudia Elera-Fitzcarrald; Cinthia Aranow; Laurent Arnaud; Anca D Askanase; Sang-Cheol Bae; Sasha Bernatsky; Ian N Bruce; Jill Buyon; Nathalie Costedoat-Chalumeau; Mary Ann Dooley; Paul R Fortin; Ellen M Ginzler; Dafna D Gladman; John Hanly; Murat Inanc; David Isenberg; Soren Jacobsen; Judith A James; Andreas Jönsen; Kenneth Kalunian; Diane L Kamen; Sung Sam Lim; Eric Morand; Marta Mosca; Christine Peschken; Bernardo A Pons-Estel; Anisur Rahman; Rosalind Ramsey-Goldman; John Reynolds; Juanita Romero-Diaz; Guillermo Ruiz-Irastorza; Jorge Sánchez-Guerrero; Elisabet Svenungsson; Murray Urowitz; Evelyne Vinet; Ronald F van Vollenhoven; Alexandre Voskuyl; Daniel J Wallace; Michelle A Petri; Susan Manzi; Ann Elaine Clarke; Mike Cheung; Vernon Farewell; Graciela S Alarcon Journal: Lupus Sci Med Date: 2021-12
Authors: Alexandra Legge; Susan Kirkland; Kenneth Rockwood; Pantelis Andreou; Sang-Cheol Bae; Caroline Gordon; Juanita Romero-Diaz; Jorge Sanchez-Guerrero; Daniel J Wallace; Sasha Bernatsky; Ann E Clarke; Joan T Merrill; Ellen M Ginzler; Paul R Fortin; Dafna D Gladman; Murray B Urowitz; Ian N Bruce; David A Isenberg; Anisur Rahman; Graciela S Alarcón; Michelle Petri; Munther A Khamashta; M A Dooley; Rosalind Ramsey-Goldman; Susan Manzi; Asad A Zoma; Cynthia Aranow; Meggan Mackay; Guillermo Ruiz-Irastorza; S Sam Lim; Murat Inanc; Ronald F van Vollenhoven; Andreas Jonsen; Ola Nived; Manuel Ramos-Casals; Diane L Kamen; Kenneth C Kalunian; Søren Jacobsen; Christine A Peschken; Anca Askanase; John G Hanly Journal: Arthritis Care Res (Hoboken) Date: 2022-02-17 Impact factor: 5.178