| Literature DB >> 31630771 |
J V Cabral-Costa1, A J Kowaltowski2.
Abstract
The brain is highly dependent on mitochondrial energy metabolism. As a result, mitochondrial dysfunction is a central aspect of many adult-onset neurological diseases, including stroke, ALS, Alzheimer's, Huntington's, and Parkinson's diseases. We review here how different mitochondrial functions, including oxidative phosphorylation, mitochondrial dynamics, oxidant generation, cell death regulation, Ca2+ homeostasis, and proteostasis are involved in these disorders.Entities:
Keywords: Calcium; Mitochondria; Mitophagy; Neurodegeneration; Reactive oxygen species
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Year: 2019 PMID： 31630771 DOI： 10.1016/j.mam.2019.10.003
Source DB: PubMed Journal: Mol Aspects Med ISSN： 0098-2997