Wei Guang Bi1,2, Elham Emami3, Zhong-Cheng Luo4, Christina Santamaria1, Shu Qin Wei1. 1. CHU Sainte-Justine Research Center, Department of Obstetrics and Gynecology, University of Montreal, Montréal, Canada. 2. Faculty of Dentistry, University of Montreal, Montréal, Canada. 3. Faculty of Dentistry, McGill University, Montréal, Canada. 4. Department of Obstetrics and Gynecology, Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, and Prosserman Centre for Population Health Research, University of Toronto, Toronto, Canada.
Abstract
OBJECTIVE: To assess the effect of periodontal treatment during pregnancy on maternal, fetal and neonatal outcomes. METHODS: This is a systematic review and meta-analysis of randomized controlled trials that evaluated the effect of treatment of periodontal diseases on pregnancy outcomes. Primary outcome was perinatal mortality. Secondary outcomes were maternal and neonatal morbidity. Outcomes were pooled using fix-effect or random effects models and presented as risk ratio (RR), or mean difference (MD), and 95% confidence interval (CI). RESULTS: Twenty randomized controlled trials involving 8171 participants were included in this study. Periodontal treatment during pregnancy was associated with significantly decreased risk of perinatal mortality [N = 5942; RR = 0.53 (0.30-0.93); p = .03; heterogeneity (I2) = 0%, Number needed to treat (NNT): 162]. Periodontal treatment during pregnancy reduced risks of preterm birth [N = 7335; RR = 0.78 (0.62-0.98); p = .03; I2 = 72%, NNT = 37]. Periodontal treatment during pregnancy significantly increased birthweight (gram) [N = 4708; MD = 200.79 (63.34-337.24); p = .004; I2 = 93%]. Periodontal treatment during pregnancy was not associated with preeclampsia, gestational diabetes, cesarean section, small for gestational age, or congenital malformations. CONCLUSION: Periodontal treatment during pregnancy reduces the risks of perinatal mortality and preterm birth, and improves birth weight.
OBJECTIVE: To assess the effect of periodontal treatment during pregnancy on maternal, fetal and neonatal outcomes. METHODS: This is a systematic review and meta-analysis of randomized controlled trials that evaluated the effect of treatment of periodontal diseases on pregnancy outcomes. Primary outcome was perinatal mortality. Secondary outcomes were maternal and neonatal morbidity. Outcomes were pooled using fix-effect or random effects models and presented as risk ratio (RR), or mean difference (MD), and 95% confidence interval (CI). RESULTS: Twenty randomized controlled trials involving 8171 participants were included in this study. Periodontal treatment during pregnancy was associated with significantly decreased risk of perinatal mortality [N = 5942; RR = 0.53 (0.30-0.93); p = .03; heterogeneity (I2) = 0%, Number needed to treat (NNT): 162]. Periodontal treatment during pregnancy reduced risks of preterm birth [N = 7335; RR = 0.78 (0.62-0.98); p = .03; I2 = 72%, NNT = 37]. Periodontal treatment during pregnancy significantly increased birthweight (gram) [N = 4708; MD = 200.79 (63.34-337.24); p = .004; I2 = 93%]. Periodontal treatment during pregnancy was not associated with preeclampsia, gestational diabetes, cesarean section, small for gestational age, or congenital malformations. CONCLUSION: Periodontal treatment during pregnancy reduces the risks of perinatal mortality and preterm birth, and improves birth weight.
Authors: Amanda Rodrigues Amorim Adegboye; Danilo Dias Santana; Pedro Paulo Teixeira Dos Santos; Paula Guedes Cocate; Camila Benaim; Maria Beatriz Trindade de Castro; Michael Maia Schlüssel; Gilberto Kac; Berit Lilienthal Heitmann Journal: Nutrients Date: 2021-02-27 Impact factor: 5.717